Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

• Published in: The Journal of experimental medicine Vol. 204; no. 10; pp. 2473 - 2485
• Main Authors: Almeida, Jorge R., Price, David A., Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, Asher, Tedi E., Samri, Assia, Schnuriger, Aurélie, Theodorou, Ioannis, Costagliola, Dominique, Rouzioux, Christine, Agut, Henri, Marcelin, Anne-Geneviève, Douek, Daniel, Autran, Brigitte, Appay, Victor
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.10.2007; The Rockefeller University Press
• Subjects: Amino Acid Sequence; CD57 Antigens - metabolism; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Cell Proliferation; Cellular Senescence; Gene Products, gag - immunology; HIV Infections - immunology; HIV Infections - metabolism; HIV Infections - pathology; HIV-1 - physiology; HLA-B27 Antigen - chemistry; HLA-B27 Antigen - immunology; Humans; Immunology; Life Sciences; Lymphocyte Count; Molecular Sequence Data; Virus Replication

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility...