Prospects of engineered bacteria-assisted CAR T Cell therapy in gastrointestinal cancers

• Published in: Oncology reviews Vol. 19; p. 1581856
• Main Authors: Zhang, Qingqing, Song, Xiao, Liu, Junhong, Zhou, Xuejiao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.04.2025
• Subjects: CAR T cell therapy; engineered bacteria; gastrointestinal cancers; immunotherapy; Oncology Reviews; tumor microenvironment; gastrointestinal cancers; CAR T cell therapy; tumor microenvironment; engineered bacteria; immunotherapy

The high incidence and mortality rates associated with gastrointestinal cancers represent a significant global health challenge. In recent years, CAR T cell therapy has emerged as a promising immunotherapeutic approach, demonstrating favorable clinical outcomes. However, the application of tradition...