Altered expression of sodium transporters in ischemic penumbra after focal cerebral ischemia in rats

• Published in: Neuroscience research Vol. 59; no. 2; pp. 152 - 159
• Main Authors: Jung, Yong-Wook, Choi, In-Jang, Kwon, Tae-Hwan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2007
• Subjects: Animals; Brain edema; Brain Edema - etiology; Brain Edema - metabolism; Brain Edema - physiopathology; Brain ischemia; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Calcium - metabolism; Calcium Signaling - physiology; Carrier Proteins - metabolism; Cerebral Infarction - metabolism; Cerebral Infarction - physiopathology; Cerebrum - metabolism; Cerebrum - physiopathology; Down-Regulation - physiology; Glial Fibrillary Acidic Protein - metabolism; Immunoblotting; Infarction, Middle Cerebral Artery - metabolism; Infarction, Middle Cerebral Artery - physiopathology; Intracellular acidosis; Ischemic penumbra; Male; Nerve Tissue Proteins - metabolism; Nuclear Proteins - metabolism; Rats; Rats, Sprague-Dawley; Sodium - metabolism; Sodium transporters; Sodium-Bicarbonate Symporters - metabolism; Sodium-Calcium Exchanger - metabolism; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers - metabolism; Sodium-Potassium-Exchanging ATPase - metabolism; Targeted proteomics; Up-Regulation - physiology; Water-Electrolyte Balance - physiology; Brain ischemia; Intracellular acidosis; Brain edema; Sodium transporters; Targeted proteomics; Ischemic penumbra

This study was aimed to examine whether the changes of protein expression of sodium transporters in the ischemic penumbra are associated with the pathogenesis of ischemia-induced brain edema and/or brain cell injury. An experimental model of cerebral ischemia was made by permanent middle cerebral ar...