Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension

• Published in: European heart journal cardiovascular imaging Vol. 20; no. 2; p. 209
• Main Authors: Friesen, Richard M, Schäfer, Michal, Ivy, D Dunbar, Abman, Steven H, Stenmark, Kurt, Browne, Lorna P, Barker, Alex J, Hunter, Kendall S, Truong, Uyen
• Format: Journal Article
• Language: English
• Published: England 01.02.2019
• Subjects: Adolescent; Child; Child, Preschool; Female; Hemodynamics; Humans; Hypertension, Pulmonary - diagnostic imaging; Hypertension, Pulmonary - physiopathology; Infant; Magnetic Resonance Angiography - methods; Male; Prognosis; Vascular Stiffness; Ventricular Dysfunction, Right - diagnostic imaging; Ventricular Dysfunction, Right - physiopathology

Main pulmonary artery (MPA) stiffness and abnormal flow haemodynamics in pulmonary arterial hypertension (PAH) are strongly associated with elevated right ventricular (RV) afterload and associated with disease severity and poor clinical outcomes in adults with PAH. However, the long-term effects of...