INFLUENCE OF THE ENDOTHELIAL NITRIC OXIDE SYNTHASE POLYMORPHISM ON THE PROGRESSION OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND IgA NEPHROPATHY

• Published in: Renal failure Vol. 24; no. 5; pp. 585 - 593
• Main Authors: Merta, Miroslav, Reiterová, Jana, Tesa, Vladimír, Štekrová, Jitka, Viklický, Ond ej
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 01.01.2002; Taylor & Francis
• Subjects: Adult; Arterial hypertension; Biological and medical sciences; Disease Progression; Endothelium - enzymology; Endothelium - physiopathology; Female; Gene Frequency - genetics; Genotype; Glomerulonephritis, IGA - enzymology; Glomerulonephritis, IGA - genetics; Glomerulonephritis, IGA - physiopathology; Humans; IgA nephropathy; Introns - genetics; Kidneys; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nitric oxide synthase; Nitric Oxide Synthase - genetics; Polycystic kidney disease; Polycystic Kidney, Autosomal Dominant - enzymology; Polycystic Kidney, Autosomal Dominant - genetics; Polycystic Kidney, Autosomal Dominant - physiopathology; Polymorphism; Polymorphism, Genetic - genetics; Renal failure; Urinary system involvement in other diseases. Miscellaneous; Kidney disease; Human; Glomerulonephritis; Immunopathology; IgA; Urinary system disease; Enzyme; Polycystic kidney; Genotype; Terminal stage; Synthase; Genetic disease; Allele; Nitric oxide; Autosomal character; Cyst; Renal failure; Dominant character; Benign neoplasm; Comparative study; Polymorphism

Background: The reason of variability of clinical course and progression to end-stage renal failure (ESRF) of two widespread chronic nephropathies-autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IGAN) is not clear. The endothelial dysfunction is considered in the number of...