O-linked β- N-acetylglucosamine ( O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

• Published in: Biochimica et biophysica acta Vol. 1800; no. 2; pp. 96 - 106
• Main Authors: Butkinaree, Chutikarn, Park, Kyoungsook, Hart, Gerald W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2010
• Subjects: Acetylglucosamine - metabolism; Acetylglucosaminidase - metabolism; Alzheimer's disease; Animals; Diabetes; Diabetes Mellitus - physiopathology; Food; Gene Expression Regulation, Enzymologic - physiology; GlcNAcylation; Glucosamine; Hexosamines - biosynthesis; Humans; N-Acetylglucosaminyltransferases - metabolism; Neurons - physiology; O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; OGA; OGT; Phosphorylation; Proteasome Endopeptidase Complex - physiology; Protein Processing, Post-Translational; Signal Transduction - physiology; Signaling; Stress; Stress, Physiological - physiology; Ubiquitination; Signaling; Phosphorylation; Glucosamine; O-GlcNAc transferase; OGA; O-GlcNAcase; GlcNAcylation; Diabetes; O-GlcNAc; OGT; Alzheimer's disease; Stress

Since its discovery in the early 1980s, O-linked-β- N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. While other forms of protein glycosylation modify proteins on the cell surface or wit...