Biotransformation of (1-phenyl)ethyl hydroperoxide with Aspergillus niger: a model study on enzyme selectivity and on the induction of peroxidase activity

• Published in: Biochimica et biophysica acta Vol. 1427; no. 2; pp. 236 - 244
• Main Authors: Adam, Waldemar, Lukacs, Zoltan, Saha-Möller, Chantu R, Schreier, Peter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 19.04.1999
• Subjects: (1-Phenyl)ethyl hydroperoxide; Aspergillus niger; Aspergillus niger - enzymology; biosynthesis; Biotransformation; Catalase; Catalase - metabolism; Cations, Divalent; Cold Temperature; Enantioselectivity; Enzyme induction; enzymology; Fungal Proteins; Fungal Proteins - biosynthesis; gene induction; induction; Kinetics; metabolism; Oxidation-Reduction; Peroxidase; Peroxidase - biosynthesis; Peroxidase - metabolism; peroxidases; peroxides; Peroxides - metabolism; Stereoisomerism; Stress response; Peroxidase; Enantioselectivity; (1-Phenyl)ethyl hydroperoxide; Stress response; Aspergillus niger; Enzyme induction

The biocatalytic enantioselective reduction of (1-phenyl)ethyl hydroperoxide ( 1) by the fungus Aspergillus niger to the corresponding alcohol 2 involves a multi-enzyme biotransformation of the hydroperoxide 1, as revealed by the change in the enantioselectivity as a function of incubation times. Th...