Effects of Fmr1 Gene Mutations on Sex Differences in Autism-Like Behavior and Dendritic Spine Development in Mice and Transcriptomic Studies

• Published in: Neuroscience Vol. 534; pp. 16 - 28
• Main Authors: Wang, Zhao, Qiao, Dan, Chen, Huan, Zhang, Shihua, Zhang, Bohan, Zhang, Jingbao, Hu, Xiangting, Wang, Chang, Cui, Huixian, Wang, Xia, Li, Sha
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2023
• Subjects: behavioral phenotype; dendritic spines; Fmr1 knockout mice; fragile X syndrome; gene transcriptome; sex difference; CC; FXS; Fmr1 knockout mice; MWM; gene transcriptome; sex difference; KO; TCT; FMRP; FST; fragile X syndrome; GO; PPI; behavioral phenotype; dendritic spines; BP; NOR; ASD; MB; MF; OFT

•Fmr1 KO mice display sex differences in autism-like behavior and dendritic spine.•Male mice have more severe effects in autism-like behavior and dendritic spine.•There is sex-biased mRNA expression in the hippocampus of Fmr1 KO mice.•Differential gene expression affects the behavior of Fmr1 KO male...