Diminished Expression of Transcription Factors Nuclear Factor κB and CCAAT/Enhancer Binding Protein Underlies a Novel Tumor Evasion Mechanism Affecting Macrophages of Mammary Tumor–Bearing Mice

• Published in: Cancer research (Chicago, Ill.) Vol. 65; no. 22; pp. 10578 - 10584
• Main Authors: Torroella-Kouri, Marta, Ma, Xiaojing, Perry, Giselle, Ivanova, Milena, Cejas, Pedro J., Owen, Jennifer L., Iragavarapu-Charyulu, Vijaya, Lopez, Diana M.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.2005
• Subjects: Antineoplastic agents; Biological and medical sciences; Gynecology. Andrology. Obstetrics; Immunotherapy; Mammary gland diseases; Medical sciences; Pharmacology. Drug treatments; Tumors; Immune response; Cytokine; Rodentia; Interleukin 12; Breast cancer; Malignant tumor; Gene expression; α-Fetoprotein; Mammary gland diseases; Binding protein; Signal transduction; Vertebrata; Mammalia; Mouse; Animal; Transcription factor NFκB; Mechanism of action; Macrophage
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/0008-5472.CAN-05-0365

Interactions between malignant tumors and the host immune system shape the course of cancer progression. The molecular basis of such interactions is the subject of immense interest. Proinflammatory cytokines produced by macrophages are critical mediators of immune responses that contribute to the co...