Biological variation of serum neurofilament light chain

• Published in: Clinical chemistry and laboratory medicine Vol. 60; no. 4; pp. 569 - 575
• Main Authors: Hviid, Claus Vinter Bødker, Madsen, Anne Tranberg, Winther-Larsen, Anne
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 28.03.2022; Walter De Gruyter & Company
• Subjects: Biological variation; biomarker; Biomarkers; Biomarkers - blood; Blood; Chains; Confidence intervals; Diurnal variations; Humans; Intermediate Filaments - metabolism; monitoring; neurofilament proteins; Neurofilament Proteins - blood; Reference Values; Variation; biomarker; monitoring; neurofilament proteins; biological variation

The neurofilament light chain (NfL) has emerged as a versatile biomarker for CNS-diseases and is approaching clinical use. The observed changes in NfL levels are frequently of limited magnitude and in order to make clinical decisions based on NfL measurements, it is essential that biological variati...