Immunodeficiency Accelerates Vitamin A Deficiency
Vitamin A deficiency increases susceptibility to infection caused by impaired immune function. We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency. Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse (nu/nu) an...
Saved in:
Published in | Current developments in nutrition Vol. 5; no. 11; p. nzab129 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.11.2021
Oxford University Press |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Vitamin A deficiency increases susceptibility to infection caused by impaired immune function.
We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency.
Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse (nu/nu) and the humoral immunodeficient SENCAR (SENsitive to CARcinogenesis) mouse. Vitamin A deficiency was also monitored in outbred Balb/c and in NIH mice. The monitoring of vitamin A deficiency was done after feeding the mice and their mothers a semisynthetic, vitamin A–deficient diet from birth of the experimental mice. These mice were weaned onto the same deficient diet at 3–4 wk of age, while control groups were fed the same diet containing 3 μg retinoic acid per gram of diet.
The immunodeficient nu/nu and SENCAR mice developed vitamin A deficiency earlier than either the heterozygous nu/+ controls or the Balb/c and NIH strains. In female mice, symptoms included depletion of liver retinol and retinyl palmitate, squamous metaplasia of the uterus, and death. Male mice lost weight more frequently and sooner than female mice, in which mortality generally occurred in the absence of loss of body weight. Pairwise comparisons using Tukey’s honest significant difference test of the nu/nu and SENCAR mice versus the Balb/c and NIH mice showed a faster loss of retinol and retinyl palmitate in all pairs (P ≤ 0.0001) except for retinol when comparing nu/nu and NIH strains (P = 0.3383).
Our findings are consistent with an increased usage of liver retinol and retinyl palmitate in the immunocompromised nu/nu and in the immunodeficient SENCAR mice and suggest that compensatory mechanisms dependent on vitamin A utilization are called upon to rescue immunodeficiency both in the T-cell–deficient phenotype of the nu/nu mice and in the humoral immunodeficient SENCAR mice. |
---|---|
AbstractList | Vitamin A deficiency increases susceptibility to infection caused by impaired immune function.
We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency.
Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse (nu/nu) and the humoral immunodeficient SENCAR (SENsitive to CARcinogenesis) mouse. Vitamin A deficiency was also monitored in outbred Balb/c and in NIH mice. The monitoring of vitamin A deficiency was done after feeding the mice and their mothers a semisynthetic, vitamin A–deficient diet from birth of the experimental mice. These mice were weaned onto the same deficient diet at 3–4 wk of age, while control groups were fed the same diet containing 3 μg retinoic acid per gram of diet.
The immunodeficient nu/nu and SENCAR mice developed vitamin A deficiency earlier than either the heterozygous nu/+ controls or the Balb/c and NIH strains. In female mice, symptoms included depletion of liver retinol and retinyl palmitate, squamous metaplasia of the uterus, and death. Male mice lost weight more frequently and sooner than female mice, in which mortality generally occurred in the absence of loss of body weight. Pairwise comparisons using Tukey’s honest significant difference test of the nu/nu and SENCAR mice versus the Balb/c and NIH mice showed a faster loss of retinol and retinyl palmitate in all pairs (P ≤ 0.0001) except for retinol when comparing nu/nu and NIH strains (P = 0.3383).
Our findings are consistent with an increased usage of liver retinol and retinyl palmitate in the immunocompromised nu/nu and in the immunodeficient SENCAR mice and suggest that compensatory mechanisms dependent on vitamin A utilization are called upon to rescue immunodeficiency both in the T-cell–deficient phenotype of the nu/nu mice and in the humoral immunodeficient SENCAR mice. Vitamin A deficiency increases susceptibility to infection caused by impaired immune function. We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency. Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse ( ) and the humoral immunodeficient SENCAR (SENsitive to CARcinogenesis) mouse. Vitamin A deficiency was also monitored in outbred Balb/c and in NIH mice. The monitoring of vitamin A deficiency was done after feeding the mice and their mothers a semisynthetic, vitamin A-deficient diet from birth of the experimental mice. These mice were weaned onto the same deficient diet at 3-4 wk of age, while control groups were fed the same diet containing 3 μg retinoic acid per gram of diet. The immunodeficient and SENCAR mice developed vitamin A deficiency earlier than either the heterozygous controls or the Balb/c and NIH strains. In female mice, symptoms included depletion of liver retinol and retinyl palmitate, squamous metaplasia of the uterus, and death. Male mice lost weight more frequently and sooner than female mice, in which mortality generally occurred in the absence of loss of body weight. Pairwise comparisons using Tukey's honest significant difference test of the and SENCAR mice versus the Balb/c and NIH mice showed a faster loss of retinol and retinyl palmitate in all pairs ( ≤ 0.0001) except for retinol when comparing and NIH strains ( = 0.3383). Our findings are consistent with an increased usage of liver retinol and retinyl palmitate in the immunocompromised and in the immunodeficient SENCAR mice and suggest that compensatory mechanisms dependent on vitamin A utilization are called upon to rescue immunodeficiency both in the T-cell-deficient phenotype of the mice and in the humoral immunodeficient SENCAR mice. ABSTRACT Background Vitamin A deficiency increases susceptibility to infection caused by impaired immune function. Objectives We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency. Methods Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse (nu/nu) and the humoral immunodeficient SENCAR (SENsitive to CARcinogenesis) mouse. Vitamin A deficiency was also monitored in outbred Balb/c and in NIH mice. The monitoring of vitamin A deficiency was done after feeding the mice and their mothers a semisynthetic, vitamin A–deficient diet from birth of the experimental mice. These mice were weaned onto the same deficient diet at 3–4 wk of age, while control groups were fed the same diet containing 3 μg retinoic acid per gram of diet. Results The immunodeficient nu/nu and SENCAR mice developed vitamin A deficiency earlier than either the heterozygous nu/+ controls or the Balb/c and NIH strains. In female mice, symptoms included depletion of liver retinol and retinyl palmitate, squamous metaplasia of the uterus, and death. Male mice lost weight more frequently and sooner than female mice, in which mortality generally occurred in the absence of loss of body weight. Pairwise comparisons using Tukey's honest significant difference test of the nu/nu and SENCAR mice versus the Balb/c and NIH mice showed a faster loss of retinol and retinyl palmitate in all pairs (P ≤ 0.0001) except for retinol when comparing nu/nu and NIH strains (P = 0.3383). Conclusions Our findings are consistent with an increased usage of liver retinol and retinyl palmitate in the immunocompromised nu/nu and in the immunodeficient SENCAR mice and suggest that compensatory mechanisms dependent on vitamin A utilization are called upon to rescue immunodeficiency both in the T-cell–deficient phenotype of the nu/nu mice and in the humoral immunodeficient SENCAR mice. |
ArticleNumber | nzab129 |
Author | De Luca, Luigi M Darwiche, Nadine Petrides, Victoria Hill Armey, Laura Palmer, Amanda West, Keith P |
Author_xml | – sequence: 1 givenname: Luigi M surname: De Luca fullname: De Luca, Luigi M email: ldeluca1@jhu.edu organization: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA – sequence: 2 givenname: Victoria Hill surname: Petrides fullname: Petrides, Victoria Hill organization: Independent Consultant, Bethesda, MD, USA – sequence: 3 givenname: Nadine surname: Darwiche fullname: Darwiche, Nadine organization: Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA – sequence: 4 givenname: Laura surname: Armey fullname: Armey, Laura organization: Naval Postgraduate School, Monterey, CA, USA – sequence: 5 givenname: Amanda surname: Palmer fullname: Palmer, Amanda organization: Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA – sequence: 6 givenname: Keith P surname: West fullname: West, Keith P organization: Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34870072$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkMtLAzEQh4NUbK09eZc9eZG1ySb7yEUorY9CwYt6DXnMaqSbLdltof71RreWCoKXTGC--c3wnaKeqx0gdE7wNcGcjrVxY_chFUn4ERokLE_jhHPSO_j30ahp3jHGhHOeYX6C-pQVOcZ5MkBkXlVrVxsorbbg9DaaaA1L8LKFJnqxraysiybRbA-coeNSLhsY7eoQPd_dPk0f4sXj_Xw6WcSakayNc5WFDTilGaVaMamlTIDkrOSqzE1gWFpkhlOjlZLGMMWYJLgIbynzcCgdopsud7VWFRgNrvVyKVbeVtJvRS2t-N1x9k281htRZJSxjISAqy5A-7ppPJT7WYLFlzwR5ImdvEBfHK7bsz-qAnDZAfV69U9S2oEQ7GwseNF8mwNjPehWmNr-OfcJfKaOXQ |
Cites_doi | 10.1016/j.rmed.2017.10.016 10.1093/ajcn/49.3.501 10.1146/annurev.nutr.21.1.167 10.3181/00379727-200-43436A 10.1016/0304-3835(95)03868-W 10.4049/jimmunol.1403061 10.3390/ijms21155570 10.1097/MCP.0000000000000647 10.1038/372103a0 10.1038/217370a0 10.1126/science.163.3867.574 10.1016/j.nut.2014.11.016 10.3181/00379727-178-41999 10.1093/carcin/14.3.539 10.2307/3001913 10.33549/physiolres.933526 10.4049/jimmunol.142.2.388 10.1111/j.1600-0625.2005.00362.x 10.1177/14.4.291 10.1093/ajcn/70.4.502 10.1017/S0016672300010168 10.1002/(SICI)1098-2744(199709)20:1<143::AID-MC16>3.0.CO;2-1 10.1016/0308-8146(93)90015-8 10.1002/eji.200425060 10.1146/annurev-animal-022516-022914 10.1182/blood.V95.11.3349 10.1016/j.toxlet.2017.05.005 10.4049/jimmunol.170.9.4564 10.1289/ehp.866827 10.1126/science.1260144 10.1016/j.jaci.2019.09.016 10.1007/s10875-005-4090-6 10.1371/journal.ppat.1004314 10.1016/j.immuni.2015.06.009 10.1074/jbc.M701700200 10.2174/1871530319666190529101816 10.1093/jn/115.7.909 10.1096/fasebj.5.14.1661245 10.1089/vim.2015.0104 10.3181/00379727-143-37487 10.1016/0003-2697(78)90802-3 10.1016/j.it.2016.12.006 |
ContentType | Journal Article |
Copyright | 2021 American Society for Nutrition. The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. |
Copyright_xml | – notice: 2021 American Society for Nutrition. – notice: The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. 2021 – notice: The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. |
DBID | 6I. AAFTH TOX NPM AAYXX CITATION 5PM |
DOI | 10.1093/cdn/nzab129 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Oxford Academic Journals (Open Access) PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: TOX name: Oxford Academic Journals (Open Access) url: https://academic.oup.com/journals/ sourceTypes: Publisher |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 2475-2991 |
ExternalDocumentID | 10_1093_cdn_nzab129 34870072 10.1093/cdn/nzab129 S2475299122106013 |
Genre | Journal Article |
GrantInformation_xml | – fundername: ; |
GroupedDBID | .1- .FO 0R~ 6I. AAFTH AAFWJ AAPXW AAVAP AAXUO ABDBF ABPTD ABXVV ACGFS ADBBV AFCTW AFPKN AFRHN AFULF AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAYMD BCNDV BTTYL EBS EJD FDB GROUPED_DOAJ HYE IAO IHR INH KSI M~E O9- OJZSN OK1 ROX RPM TOX Z5R 0SF AAHBH AALRI ADVLN AITUG H13 AFJKZ ITC NPM AAYXX CITATION 5PM |
ID | FETCH-LOGICAL-c416t-7b6007053633cb4acaa2e174f9bf7dc414586d93dcbbadd4b44a10844afa79993 |
IEDL.DBID | RPM |
ISSN | 2475-2991 |
IngestDate | Tue Sep 17 21:22:48 EDT 2024 Thu Sep 26 19:19:50 EDT 2024 Wed Oct 09 10:31:19 EDT 2024 Wed Aug 28 03:18:48 EDT 2024 Fri Feb 23 02:36:48 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Keywords | athymic mice retinyl palmitate SENCAR (SENsitive to CARcinogenesis) mice Fox Rol BHT RA retinol NCI HSD immunodeficiency vitamin A deficiency RP |
Language | English |
License | http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c416t-7b6007053633cb4acaa2e174f9bf7dc414586d93dcbbadd4b44a10844afa79993 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634461/ |
PMID | 34870072 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8634461 crossref_primary_10_1093_cdn_nzab129 pubmed_primary_34870072 oup_primary_10_1093_cdn_nzab129 elsevier_sciencedirect_doi_10_1093_cdn_nzab129 |
PublicationCentury | 2000 |
PublicationDate | 2021-11-01 |
PublicationDateYYYYMMDD | 2021-11-01 |
PublicationDate_xml | – month: 11 year: 2021 text: 2021-11-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Current developments in nutrition |
PublicationTitleAlternate | Curr Dev Nutr |
PublicationYear | 2021 |
Publisher | Elsevier Inc Oxford University Press |
Publisher_xml | – name: Elsevier Inc – name: Oxford University Press |
References | Kuzin, Ugine, Barth, Shultz, Nahm, Young, Bottaro (bib26) 2004; 34 Hurwitz, Penkert, Xu, Fan, Partridge, Maul, Gearhart (bib53) 2016; 29 Berger, Geng, Cameron, Murphy, Schulman (bib3) 2017; 132 De Luca, Shores, Spangler, Wenk (bib27) 1989; 49 Kim, Taparowsky, Kim (bib48) 2015; 43 Bahari, Salmani (bib6) 2017; 275 Bieri, McDaniel, Rogers (bib11) 1969; 163 Milliken, Johnson (bib36) 2009 Tanaka, Suh, Lo, De Luca (bib41) 2007; 282 Sommer, West (bib38) 1996 Anderson, McCarthy (bib23) 2015; 194 Darwiche, Celli, Sly, Lancillotti, De Luca (bib30) 1993; 53 Chen, Tarone, Huynh, De Luca (bib45) 1995; 95 Verma, Shapas, Rice, Boutwell (bib42) 1979; 39 Wolf, De Luca (bib51) 1970 Smith, Panickar, Urban, Dawson (bib10) 2018; 6 De Luca (bib52) 1991; 5 Mace, Orange (bib2) 2016; 7 Slaga (bib24) 1986; 68 Vargas-Hernández (bib1) 2020; 145 Frolik, Tavela, Peck, Sporn (bib29) 1978; 86 Graham, Karnovsky (bib33) 1966; 14 Snedecor, Cochran (bib34) 1980 Barua, Furr, Janick-Buckner, Olson (bib28) 1993; 46 Surman, Penkert, Sealy, Jones, Marion, Vogel, Hurwitz (bib54) 2020; 21 De Luca, Wolf (bib50) 1969; 22 Ponnamperuma, Kirchhof, Trifiletti, De Luca (bib31) 1999; 70 Elmadfa, Meyer (bib7) 2019; 19 Pasatiempo, Bowman, Taylor, Ross (bib13) 1989; 49 Stephensen (bib8) 2001; 21 Bang, Foard, Bang (bib15) 1973; 143 Ramachandran, Santha, Garg, Baskaran, Iliayas, Venkatesan, Fathima, Narayanan (bib40) 2004; 8 Belkaid, Segre (bib5) 2014; 346 De Luca, Sly, Jones, Chen (bib44) 1993; 14 Thurnheer, Zuercher, Cebra, Bos (bib49) 2003; 170 Ongsakul, Sirisinha, Lamb (bib16) 1985; 178 Carman, Smith, Hayes (bib12) 1989; 142 Nauss, Phua, Ambrogi, Newberne (bib14) 1985; 115 Kuwata, Wang, Tamura, Ponnamperuma, Levine, Holmes, Morse, De Luca, Ozato (bib43) 2000; 95 Palmer, Schulze, Khatry, De Luca, West (bib46) 2015; 31 Erkelens, Mebius (bib47) 2017; 38 Szadvari, Krizanova, Babula (bib19) 2016; 65 Sun, Li, Luo, Zhao (bib22) 2014; 2014 Mechlenburg, Tychsen, Paus (bib20) 2005; 14 Gill, Frost, Miller (bib32) 1974; 18 Ross (bib9) 1992; 200 Pantelouris (bib18) 1968; 217 Van der Veen, de Groot, Melgert (bib4) 2020; 26 Tukey (bib35) 1949; 5 Nehls, Pfeifer, Schorpp, Hedrich, Boehm (bib21) 1994; 372 Hennings, Lowry, Yuspa, Mock, Potter (bib25) 1997; 20 Flanagan (bib17) 1966; 8 Handisurya, Day, Thompson, Bonelli, Lowy, Schiller (bib37) 2014; 10 Kilic, Kezer, Ilcol, Yakut, Aydin, Ulus (bib39) 2005; 25 Tukey (10.1093/cdn/nzab129_bib35) 1949; 5 Mechlenburg (10.1093/cdn/nzab129_bib20) 2005; 14 Elmadfa (10.1093/cdn/nzab129_bib7) 2019; 19 Hurwitz (10.1093/cdn/nzab129_bib53) 2016; 29 Slaga (10.1093/cdn/nzab129_bib24) 1986; 68 Flanagan (10.1093/cdn/nzab129_bib17) 1966; 8 Nauss (10.1093/cdn/nzab129_bib14) 1985; 115 Chen (10.1093/cdn/nzab129_bib45) 1995; 95 Hennings (10.1093/cdn/nzab129_bib25) 1997; 20 Barua (10.1093/cdn/nzab129_bib28) 1993; 46 Pantelouris (10.1093/cdn/nzab129_bib18) 1968; 217 De Luca (10.1093/cdn/nzab129_bib44) 1993; 14 Bahari (10.1093/cdn/nzab129_bib6) 2017; 275 Nehls (10.1093/cdn/nzab129_bib21) 1994; 372 Darwiche (10.1093/cdn/nzab129_bib30) 1993; 53 Ramachandran (10.1093/cdn/nzab129_bib40) 2004; 8 Stephensen (10.1093/cdn/nzab129_bib8) 2001; 21 Bang (10.1093/cdn/nzab129_bib15) 1973; 143 De Luca (10.1093/cdn/nzab129_bib50) 1969; 22 Kim (10.1093/cdn/nzab129_bib48) 2015; 43 De Luca (10.1093/cdn/nzab129_bib52) 1991; 5 Bieri (10.1093/cdn/nzab129_bib11) 1969; 163 Belkaid (10.1093/cdn/nzab129_bib5) 2014; 346 Wolf (10.1093/cdn/nzab129_bib51) 1970 Verma (10.1093/cdn/nzab129_bib42) 1979; 39 Kilic (10.1093/cdn/nzab129_bib39) 2005; 25 Kuwata (10.1093/cdn/nzab129_bib43) 2000; 95 Sommer (10.1093/cdn/nzab129_bib38) 1996 Snedecor (10.1093/cdn/nzab129_bib34) 1980 Kuzin (10.1093/cdn/nzab129_bib26) 2004; 34 Tanaka (10.1093/cdn/nzab129_bib41) 2007; 282 Sun (10.1093/cdn/nzab129_bib22) 2014; 2014 Frolik (10.1093/cdn/nzab129_bib29) 1978; 86 Palmer (10.1093/cdn/nzab129_bib46) 2015; 31 Smith (10.1093/cdn/nzab129_bib10) 2018; 6 Ongsakul (10.1093/cdn/nzab129_bib16) 1985; 178 Berger (10.1093/cdn/nzab129_bib3) 2017; 132 Vargas-Hernández (10.1093/cdn/nzab129_bib1) 2020; 145 Carman (10.1093/cdn/nzab129_bib12) 1989; 142 Handisurya (10.1093/cdn/nzab129_bib37) 2014; 10 Gill (10.1093/cdn/nzab129_bib32) 1974; 18 Pasatiempo (10.1093/cdn/nzab129_bib13) 1989; 49 Surman (10.1093/cdn/nzab129_bib54) 2020; 21 De Luca (10.1093/cdn/nzab129_bib27) 1989; 49 Erkelens (10.1093/cdn/nzab129_bib47) 2017; 38 Mace (10.1093/cdn/nzab129_bib2) 2016; 7 Graham (10.1093/cdn/nzab129_bib33) 1966; 14 Milliken (10.1093/cdn/nzab129_bib36) 2009 Thurnheer (10.1093/cdn/nzab129_bib49) 2003; 170 Van der Veen (10.1093/cdn/nzab129_bib4) 2020; 26 Szadvari (10.1093/cdn/nzab129_bib19) 2016; 65 Anderson (10.1093/cdn/nzab129_bib23) 2015; 194 Ross (10.1093/cdn/nzab129_bib9) 1992; 200 Ponnamperuma (10.1093/cdn/nzab129_bib31) 1999; 70 |
References_xml | – volume: 170 start-page: 4564 year: 2003 end-page: 4571 ident: bib49 article-title: B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice publication-title: J Immunol. contributor: fullname: Bos – volume: 95 start-page: 3349 year: 2000 end-page: 3356 ident: bib43 article-title: Vitamin A deficiency in mice causes a systemic expansion of myeloid cells publication-title: Blood. contributor: fullname: Ozato – volume: 14 start-page: 291 year: 1966 end-page: 302 ident: bib33 article-title: The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique publication-title: J Histochem Cytochem. contributor: fullname: Karnovsky – volume: 68 start-page: 27 year: 1986 end-page: 32 ident: bib24 article-title: SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice publication-title: Environ Health Perspect. contributor: fullname: Slaga – volume: 346 start-page: 954 year: 2014 end-page: 959 ident: bib5 article-title: Dialogue between skin microbiota and immunity publication-title: Science. contributor: fullname: Segre – volume: 21 start-page: 167 year: 2001 end-page: 192 ident: bib8 article-title: Vitamin A, infection, and immune function publication-title: Annu Rev Nutr. contributor: fullname: Stephensen – volume: 115 start-page: 909 year: 1985 end-page: 918 ident: bib14 article-title: Immunological changes during progressive stages of vitamin A deficiency in the rat publication-title: J Nutr. contributor: fullname: Newberne – volume: 194 start-page: 847 year: 2015 end-page: 848 ident: bib23 article-title: Laying bare the nude mouse gene publication-title: J Immunol. contributor: fullname: McCarthy – volume: 25 start-page: 275 year: 2005 end-page: 280 ident: bib39 article-title: Vitamin A deficiency in patients with common variable immunodeficiency publication-title: J Clin Immunol. contributor: fullname: Ulus – year: 1996 ident: bib38 article-title: Vitamin A deficiency: health, vision and survival. contributor: fullname: West – volume: 178 start-page: 204 year: 1985 end-page: 208 ident: bib16 article-title: Impaired blood clearance of bacteria and phagocytic activity in vitamin A-deficient rats publication-title: Exp Biol Med. contributor: fullname: Lamb – volume: 65 start-page: S441 year: 2016 end-page: S453 ident: bib19 article-title: Athymic nude mice as an experimental model for cancer treatment publication-title: Physiol Res. contributor: fullname: Babula – volume: 372 start-page: 103 year: 1994 end-page: 107 ident: bib21 article-title: New member of the winged-helix protein family disrupted in mouse and rat nude mutations publication-title: Nature. contributor: fullname: Boehm – volume: 38 start-page: 168 year: 2017 end-page: 180 ident: bib47 article-title: Retinoic acid and immune homeostasis: a balancing act publication-title: Trends Immunol. contributor: fullname: Mebius – volume: 53 start-page: 2287 year: 1993 end-page: 2299 ident: bib30 article-title: Retinoid status controls the appearance of reserve cells and keratin expression in mouse cervical epithelium publication-title: Cancer Res. contributor: fullname: De Luca – volume: 14 start-page: 797 year: 2005 end-page: 810 ident: bib20 article-title: Learning from nudity: lessons from the nude phenotype publication-title: Exp Dermatol. contributor: fullname: Paus – volume: 8 start-page: 1130 year: 2004 end-page: 1133 ident: bib40 article-title: Vitamin A levels in sputum-positive pulmonary tuberculosis patients in comparison with household contacts and healthy ‘normals’ publication-title: Int J Tuberc Lung Dis. contributor: fullname: Narayanan – volume: 22 start-page: 1050 year: 1969 end-page: 1052 ident: bib50 article-title: Vitamin A and protein synthesis in mucous membranes publication-title: Am J Clin Nutr. contributor: fullname: Wolf – volume: 142 start-page: 388 year: 1989 end-page: 393 ident: bib12 article-title: Characterization of a helper T lymphocyte defect in vitamin A-deficient mice publication-title: J Immunol. contributor: fullname: Hayes – year: 2009 ident: bib36 article-title: Analysis of messy data volume 1: designed experiments. contributor: fullname: Johnson – volume: 145 start-page: 345 year: 2020 end-page: 357 ident: bib1 article-title: Human signal transducer and activator of transcription 5b ( publication-title: J Allergy Clin Immunol. contributor: fullname: Vargas-Hernández – volume: 29 start-page: 132 year: 2016 end-page: 136 ident: bib53 article-title: Hotspots for vitamin-steroid-thyroid hormone response elements within switch regions of immunoglobulin heavy chain loci predict a direct influence of vitamins and hormones on B cell class switch recombination publication-title: Viral Immunol. contributor: fullname: Gearhart – volume: 26 start-page: 62 year: 2020 end-page: 68 ident: bib4 article-title: The different faces of the macrophage in asthma publication-title: Curr Opin Pulm Med. contributor: fullname: Melgert – volume: 5 start-page: 99 year: 1949 end-page: 11436 ident: bib35 article-title: Comparing individual means in the analysis of variance publication-title: Biometrics. contributor: fullname: Tukey – volume: 95 start-page: 113 year: 1995 end-page: 118 ident: bib45 article-title: High dietary retinoic acid inhibits tumor promotion and malignant conversion in a two-stage skin carcinogenesis protocol using 7,12-dimethylbenz[a]anthracene as the initiator and mezerein as the tumor promoter in female SENCAR mice publication-title: Cancer Lett. contributor: fullname: De Luca – volume: 5 start-page: 2924 year: 1991 end-page: 2933 ident: bib52 article-title: Retinoids and their receptors in differentiation, embryogenesis, and neoplasia publication-title: FASEB J. contributor: fullname: De Luca – volume: 34 start-page: 1807 year: 2004 end-page: 1816 ident: bib26 article-title: A new murine model of humoral immune-deficiency specifically affects class switching to T-independent antigens publication-title: Eur J Immunol. contributor: fullname: Bottaro – volume: 10 start-page: e1004314 year: 2014 ident: bib37 article-title: Strain-specific properties and t cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1 publication-title: PLoS Pathog. contributor: fullname: Schiller – volume: 132 start-page: 181 year: 2017 end-page: 188 ident: bib3 article-title: Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease publication-title: Respir Med. contributor: fullname: Schulman – volume: 275 start-page: 118 year: 2017 end-page: 122 ident: bib6 article-title: Environmentally relevant dose of arsenic interferes in functions of human monocytes derived dendritic cells publication-title: Toxicol Lett. contributor: fullname: Salmani – volume: 6 start-page: 227 year: 2018 end-page: 254 ident: bib10 article-title: Impact of micronutrients on the immune response of animals publication-title: Ann Rev Anim Biosci. contributor: fullname: Dawson – volume: 143 start-page: 1140 year: 1973 end-page: 1146 ident: bib15 article-title: The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in chickens publication-title: Exp Biol Med. contributor: fullname: Bang – volume: 163 start-page: 574 year: 1969 end-page: 575 ident: bib11 article-title: Survival of germfree rats without vitamin A publication-title: Science. contributor: fullname: Rogers – volume: 43 start-page: 107 year: 2015 end-page: 119 ident: bib48 article-title: Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut publication-title: Immunity. contributor: fullname: Kim – volume: 39 start-page: 419 year: 1979 end-page: 425 ident: bib42 article-title: Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion publication-title: Cancer Res. contributor: fullname: Boutwell – volume: 46 start-page: 419 year: 1993 end-page: 424 ident: bib28 article-title: Simultaneous analysis of individual carotenoids, retinol, retinyl esters and tochopherols in serum by isocratic non-aqueous reverse phase HPLC publication-title: Food Chem. contributor: fullname: Olson – volume: 21 start-page: 5570 year: 2020 ident: bib54 article-title: Consequences of vitamin A deficiency: immunoglobulin dysregulation, squamous cell metaplasia, infectious disease, and death publication-title: Int J Mol Sci. contributor: fullname: Hurwitz – volume: 49 start-page: 501 year: 1989 end-page: 510 ident: bib13 article-title: Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III) publication-title: Am J Clin Nutr. contributor: fullname: Ross – volume: 49 start-page: 5400 year: 1989 end-page: 5406 ident: bib27 article-title: Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene publication-title: Cancer Res. contributor: fullname: Wenk – volume: 70 start-page: 502 year: 1999 end-page: 508 ident: bib31 article-title: Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet publication-title: Am J Clin Nutr. contributor: fullname: De Luca – volume: 7 start-page: 1 year: 2016 end-page: 8 ident: bib2 article-title: Genetic causes of human NK cell deficiency and their effect on NK cell subsets publication-title: Front Immunol. contributor: fullname: Orange – volume: 200 start-page: 303 year: 1992 end-page: 320 ident: bib9 article-title: Vitamin A status: relationship to immunity and the antibody response publication-title: Exp Biol Med. contributor: fullname: Ross – volume: 14 start-page: 539 year: 1993 end-page: 542 ident: bib44 article-title: Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice publication-title: Carcinogenesis. contributor: fullname: Chen – volume: 8 start-page: 295 year: 1966 end-page: 309 ident: bib17 article-title: ‘Nude’, a new hairless gene with pleiotropic effects in the mouse publication-title: Genet Res. contributor: fullname: Flanagan – volume: 31 start-page: 813 year: 2015 end-page: 819 ident: bib46 article-title: Maternal vitamin A supplementation increases natural antibody concentrations of preadolescent offspring in rural Nepal publication-title: Nutrition. contributor: fullname: West – start-page: 257 year: 1970 end-page: 265 ident: bib51 article-title: Recent studies on some metabolic functions of vitamin A publication-title: The fat-soluble vitamins. contributor: fullname: De Luca – volume: 19 start-page: 1100 year: 2019 end-page: 1115 ident: bib7 article-title: The role of the status of selected micronutrients in shaping the immune function publication-title: Endocr Metab Immune Disord Drug Targets. contributor: fullname: Meyer – volume: 18 start-page: 300 year: 1974 end-page: 311 ident: bib32 article-title: A new formula for a half-oxidized hematoxylin solution that neither overstains nor requires differentiation publication-title: Acta Cytol. contributor: fullname: Miller – volume: 282 start-page: 29987 year: 2007 end-page: 29997 ident: bib41 article-title: P21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer publication-title: J Biol Chem. contributor: fullname: De Luca – volume: 2014 start-page: 206929 year: 2014 ident: bib22 article-title: Thymic epithelial cell development and its dysfunction in human diseases publication-title: Biomed Res Int. contributor: fullname: Zhao – volume: 20 start-page: 143 year: 1997 end-page: 150 ident: bib25 article-title: New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin publication-title: Mol Carcinog. contributor: fullname: Potter – volume: 217 start-page: 370 year: 1968 end-page: 371 ident: bib18 article-title: Absence of thymus in a mouse mutant publication-title: Nature. contributor: fullname: Pantelouris – year: 1980 ident: bib34 article-title: Statistical methods. contributor: fullname: Cochran – volume: 86 start-page: 743 year: 1978 end-page: 750 ident: bib29 article-title: High-pressure liquid chromatographic determination of 13-cis-retinoic acid and all- publication-title: Anal Biochem. contributor: fullname: Sporn – year: 1980 ident: 10.1093/cdn/nzab129_bib34 contributor: fullname: Snedecor – volume: 22 start-page: 1050 issue: 8 year: 1969 ident: 10.1093/cdn/nzab129_bib50 article-title: Vitamin A and protein synthesis in mucous membranes publication-title: Am J Clin Nutr. contributor: fullname: De Luca – start-page: 257 year: 1970 ident: 10.1093/cdn/nzab129_bib51 article-title: Recent studies on some metabolic functions of vitamin A contributor: fullname: Wolf – year: 1996 ident: 10.1093/cdn/nzab129_bib38 contributor: fullname: Sommer – volume: 132 start-page: 181 year: 2017 ident: 10.1093/cdn/nzab129_bib3 article-title: Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease publication-title: Respir Med. doi: 10.1016/j.rmed.2017.10.016 contributor: fullname: Berger – volume: 49 start-page: 501 issue: 3 year: 1989 ident: 10.1093/cdn/nzab129_bib13 article-title: Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III) publication-title: Am J Clin Nutr. doi: 10.1093/ajcn/49.3.501 contributor: fullname: Pasatiempo – volume: 21 start-page: 167 issue: 1 year: 2001 ident: 10.1093/cdn/nzab129_bib8 article-title: Vitamin A, infection, and immune function publication-title: Annu Rev Nutr. doi: 10.1146/annurev.nutr.21.1.167 contributor: fullname: Stephensen – volume: 200 start-page: 303 issue: 3 year: 1992 ident: 10.1093/cdn/nzab129_bib9 article-title: Vitamin A status: relationship to immunity and the antibody response publication-title: Exp Biol Med. doi: 10.3181/00379727-200-43436A contributor: fullname: Ross – volume: 95 start-page: 113 issue: 1-2 year: 1995 ident: 10.1093/cdn/nzab129_bib45 article-title: High dietary retinoic acid inhibits tumor promotion and malignant conversion in a two-stage skin carcinogenesis protocol using 7,12-dimethylbenz[a]anthracene as the initiator and mezerein as the tumor promoter in female SENCAR mice publication-title: Cancer Lett. doi: 10.1016/0304-3835(95)03868-W contributor: fullname: Chen – volume: 194 start-page: 847 issue: 3 year: 2015 ident: 10.1093/cdn/nzab129_bib23 article-title: Laying bare the nude mouse gene publication-title: J Immunol. doi: 10.4049/jimmunol.1403061 contributor: fullname: Anderson – volume: 21 start-page: 5570 issue: 15 year: 2020 ident: 10.1093/cdn/nzab129_bib54 article-title: Consequences of vitamin A deficiency: immunoglobulin dysregulation, squamous cell metaplasia, infectious disease, and death publication-title: Int J Mol Sci. doi: 10.3390/ijms21155570 contributor: fullname: Surman – volume: 26 start-page: 62 issue: 1 year: 2020 ident: 10.1093/cdn/nzab129_bib4 article-title: The different faces of the macrophage in asthma publication-title: Curr Opin Pulm Med. doi: 10.1097/MCP.0000000000000647 contributor: fullname: Van der Veen – volume: 372 start-page: 103 issue: 6501 year: 1994 ident: 10.1093/cdn/nzab129_bib21 article-title: New member of the winged-helix protein family disrupted in mouse and rat nude mutations publication-title: Nature. doi: 10.1038/372103a0 contributor: fullname: Nehls – volume: 217 start-page: 370 issue: 5126 year: 1968 ident: 10.1093/cdn/nzab129_bib18 article-title: Absence of thymus in a mouse mutant publication-title: Nature. doi: 10.1038/217370a0 contributor: fullname: Pantelouris – volume: 8 start-page: 1130 issue: 9 year: 2004 ident: 10.1093/cdn/nzab129_bib40 article-title: Vitamin A levels in sputum-positive pulmonary tuberculosis patients in comparison with household contacts and healthy ‘normals’ publication-title: Int J Tuberc Lung Dis. contributor: fullname: Ramachandran – year: 2009 ident: 10.1093/cdn/nzab129_bib36 contributor: fullname: Milliken – volume: 163 start-page: 574 issue: 3867 year: 1969 ident: 10.1093/cdn/nzab129_bib11 article-title: Survival of germfree rats without vitamin A publication-title: Science. doi: 10.1126/science.163.3867.574 contributor: fullname: Bieri – volume: 31 start-page: 813 issue: 6 year: 2015 ident: 10.1093/cdn/nzab129_bib46 article-title: Maternal vitamin A supplementation increases natural antibody concentrations of preadolescent offspring in rural Nepal publication-title: Nutrition. doi: 10.1016/j.nut.2014.11.016 contributor: fullname: Palmer – volume: 178 start-page: 204 issue: 2 year: 1985 ident: 10.1093/cdn/nzab129_bib16 article-title: Impaired blood clearance of bacteria and phagocytic activity in vitamin A-deficient rats publication-title: Exp Biol Med. doi: 10.3181/00379727-178-41999 contributor: fullname: Ongsakul – volume: 14 start-page: 539 issue: 3 year: 1993 ident: 10.1093/cdn/nzab129_bib44 article-title: Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice publication-title: Carcinogenesis. doi: 10.1093/carcin/14.3.539 contributor: fullname: De Luca – volume: 5 start-page: 99 issue: 2 year: 1949 ident: 10.1093/cdn/nzab129_bib35 article-title: Comparing individual means in the analysis of variance publication-title: Biometrics. doi: 10.2307/3001913 contributor: fullname: Tukey – volume: 65 start-page: S441 issue: Suppl 4 year: 2016 ident: 10.1093/cdn/nzab129_bib19 article-title: Athymic nude mice as an experimental model for cancer treatment publication-title: Physiol Res. doi: 10.33549/physiolres.933526 contributor: fullname: Szadvari – volume: 142 start-page: 388 issue: 2 year: 1989 ident: 10.1093/cdn/nzab129_bib12 article-title: Characterization of a helper T lymphocyte defect in vitamin A-deficient mice publication-title: J Immunol. doi: 10.4049/jimmunol.142.2.388 contributor: fullname: Carman – volume: 18 start-page: 300 issue: 4 year: 1974 ident: 10.1093/cdn/nzab129_bib32 article-title: A new formula for a half-oxidized hematoxylin solution that neither overstains nor requires differentiation publication-title: Acta Cytol. contributor: fullname: Gill – volume: 14 start-page: 797 issue: 11 year: 2005 ident: 10.1093/cdn/nzab129_bib20 article-title: Learning from nudity: lessons from the nude phenotype publication-title: Exp Dermatol. doi: 10.1111/j.1600-0625.2005.00362.x contributor: fullname: Mechlenburg – volume: 14 start-page: 291 issue: 4 year: 1966 ident: 10.1093/cdn/nzab129_bib33 article-title: The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique publication-title: J Histochem Cytochem. doi: 10.1177/14.4.291 contributor: fullname: Graham – volume: 70 start-page: 502 issue: 4 year: 1999 ident: 10.1093/cdn/nzab129_bib31 article-title: Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet publication-title: Am J Clin Nutr. doi: 10.1093/ajcn/70.4.502 contributor: fullname: Ponnamperuma – volume: 8 start-page: 295 issue: 3 year: 1966 ident: 10.1093/cdn/nzab129_bib17 article-title: ‘Nude’, a new hairless gene with pleiotropic effects in the mouse publication-title: Genet Res. doi: 10.1017/S0016672300010168 contributor: fullname: Flanagan – volume: 20 start-page: 143 issue: 1 year: 1997 ident: 10.1093/cdn/nzab129_bib25 article-title: New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin publication-title: Mol Carcinog. doi: 10.1002/(SICI)1098-2744(199709)20:1<143::AID-MC16>3.0.CO;2-1 contributor: fullname: Hennings – volume: 7 start-page: 1 issue: 545 year: 2016 ident: 10.1093/cdn/nzab129_bib2 article-title: Genetic causes of human NK cell deficiency and their effect on NK cell subsets publication-title: Front Immunol. contributor: fullname: Mace – volume: 46 start-page: 419 issue: 4 year: 1993 ident: 10.1093/cdn/nzab129_bib28 article-title: Simultaneous analysis of individual carotenoids, retinol, retinyl esters and tochopherols in serum by isocratic non-aqueous reverse phase HPLC publication-title: Food Chem. doi: 10.1016/0308-8146(93)90015-8 contributor: fullname: Barua – volume: 34 start-page: 1807 issue: 7 year: 2004 ident: 10.1093/cdn/nzab129_bib26 article-title: A new murine model of humoral immune-deficiency specifically affects class switching to T-independent antigens publication-title: Eur J Immunol. doi: 10.1002/eji.200425060 contributor: fullname: Kuzin – volume: 6 start-page: 227 issue: 1 year: 2018 ident: 10.1093/cdn/nzab129_bib10 article-title: Impact of micronutrients on the immune response of animals publication-title: Ann Rev Anim Biosci. doi: 10.1146/annurev-animal-022516-022914 contributor: fullname: Smith – volume: 39 start-page: 419 issue: 2 Pt 1 year: 1979 ident: 10.1093/cdn/nzab129_bib42 article-title: Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion publication-title: Cancer Res. contributor: fullname: Verma – volume: 95 start-page: 3349 issue: 11 year: 2000 ident: 10.1093/cdn/nzab129_bib43 article-title: Vitamin A deficiency in mice causes a systemic expansion of myeloid cells publication-title: Blood. doi: 10.1182/blood.V95.11.3349 contributor: fullname: Kuwata – volume: 275 start-page: 118 year: 2017 ident: 10.1093/cdn/nzab129_bib6 article-title: Environmentally relevant dose of arsenic interferes in functions of human monocytes derived dendritic cells publication-title: Toxicol Lett. doi: 10.1016/j.toxlet.2017.05.005 contributor: fullname: Bahari – volume: 170 start-page: 4564 issue: 9 year: 2003 ident: 10.1093/cdn/nzab129_bib49 article-title: B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice publication-title: J Immunol. doi: 10.4049/jimmunol.170.9.4564 contributor: fullname: Thurnheer – volume: 68 start-page: 27 year: 1986 ident: 10.1093/cdn/nzab129_bib24 article-title: SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice publication-title: Environ Health Perspect. doi: 10.1289/ehp.866827 contributor: fullname: Slaga – volume: 346 start-page: 954 issue: 6212 year: 2014 ident: 10.1093/cdn/nzab129_bib5 article-title: Dialogue between skin microbiota and immunity publication-title: Science. doi: 10.1126/science.1260144 contributor: fullname: Belkaid – volume: 53 start-page: 2287 issue: 10 Suppl year: 1993 ident: 10.1093/cdn/nzab129_bib30 article-title: Retinoid status controls the appearance of reserve cells and keratin expression in mouse cervical epithelium publication-title: Cancer Res. contributor: fullname: Darwiche – volume: 145 start-page: 345 issue: 1 year: 2020 ident: 10.1093/cdn/nzab129_bib1 article-title: Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2019.09.016 contributor: fullname: Vargas-Hernández – volume: 25 start-page: 275 issue: 3 year: 2005 ident: 10.1093/cdn/nzab129_bib39 article-title: Vitamin A deficiency in patients with common variable immunodeficiency publication-title: J Clin Immunol. doi: 10.1007/s10875-005-4090-6 contributor: fullname: Kilic – volume: 10 start-page: e1004314 issue: 8 year: 2014 ident: 10.1093/cdn/nzab129_bib37 article-title: Strain-specific properties and t cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1004314 contributor: fullname: Handisurya – volume: 43 start-page: 107 issue: 1 year: 2015 ident: 10.1093/cdn/nzab129_bib48 article-title: Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut publication-title: Immunity. doi: 10.1016/j.immuni.2015.06.009 contributor: fullname: Kim – volume: 282 start-page: 29987 issue: 41 year: 2007 ident: 10.1093/cdn/nzab129_bib41 article-title: P21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer publication-title: J Biol Chem. doi: 10.1074/jbc.M701700200 contributor: fullname: Tanaka – volume: 19 start-page: 1100 issue: 8 year: 2019 ident: 10.1093/cdn/nzab129_bib7 article-title: The role of the status of selected micronutrients in shaping the immune function publication-title: Endocr Metab Immune Disord Drug Targets. doi: 10.2174/1871530319666190529101816 contributor: fullname: Elmadfa – volume: 115 start-page: 909 issue: 7 year: 1985 ident: 10.1093/cdn/nzab129_bib14 article-title: Immunological changes during progressive stages of vitamin A deficiency in the rat publication-title: J Nutr. doi: 10.1093/jn/115.7.909 contributor: fullname: Nauss – volume: 2014 start-page: 206929 year: 2014 ident: 10.1093/cdn/nzab129_bib22 article-title: Thymic epithelial cell development and its dysfunction in human diseases publication-title: Biomed Res Int. contributor: fullname: Sun – volume: 5 start-page: 2924 issue: 14 year: 1991 ident: 10.1093/cdn/nzab129_bib52 article-title: Retinoids and their receptors in differentiation, embryogenesis, and neoplasia publication-title: FASEB J. doi: 10.1096/fasebj.5.14.1661245 contributor: fullname: De Luca – volume: 29 start-page: 132 issue: 2 year: 2016 ident: 10.1093/cdn/nzab129_bib53 article-title: Hotspots for vitamin-steroid-thyroid hormone response elements within switch regions of immunoglobulin heavy chain loci predict a direct influence of vitamins and hormones on B cell class switch recombination publication-title: Viral Immunol. doi: 10.1089/vim.2015.0104 contributor: fullname: Hurwitz – volume: 143 start-page: 1140 issue: 4 year: 1973 ident: 10.1093/cdn/nzab129_bib15 article-title: The effect of vitamin A deficiency and Newcastle disease on lymphoid cell systems in chickens publication-title: Exp Biol Med. doi: 10.3181/00379727-143-37487 contributor: fullname: Bang – volume: 86 start-page: 743 issue: 2 year: 1978 ident: 10.1093/cdn/nzab129_bib29 article-title: High-pressure liquid chromatographic determination of 13-cis-retinoic acid and all-trans-retinoic acid in human plasma publication-title: Anal Biochem. doi: 10.1016/0003-2697(78)90802-3 contributor: fullname: Frolik – volume: 49 start-page: 5400 issue: 19 year: 1989 ident: 10.1093/cdn/nzab129_bib27 article-title: Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene publication-title: Cancer Res. contributor: fullname: De Luca – volume: 38 start-page: 168 issue: 3 year: 2017 ident: 10.1093/cdn/nzab129_bib47 article-title: Retinoic acid and immune homeostasis: a balancing act publication-title: Trends Immunol. doi: 10.1016/j.it.2016.12.006 contributor: fullname: Erkelens |
SSID | ssj0001999609 |
Score | 2.217821 |
Snippet | Vitamin A deficiency increases susceptibility to infection caused by impaired immune function.
We investigated whether immunodeficiency could facilitate the... ABSTRACT Background Vitamin A deficiency increases susceptibility to infection caused by impaired immune function. Objectives We investigated whether... |
SourceID | pubmedcentral crossref pubmed oup elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | nzab129 |
SubjectTerms | athymic mice immunodeficiency Original Research retinol retinyl palmitate SENCAR (SENsitive to CARcinogenesis) mice vitamin A deficiency |
Title | Immunodeficiency Accelerates Vitamin A Deficiency |
URI | https://dx.doi.org/10.1093/cdn/nzab129 https://www.ncbi.nlm.nih.gov/pubmed/34870072 https://pubmed.ncbi.nlm.nih.gov/PMC8634461 |
Volume | 5 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT8JAEJ0AB8PFqPiBH9gD8VZa2G0LR4ISNEE9gOHW7E63kUQWonjQX-_stiWSqAcve-ls07zd7JvXzrwCNEWKMvLbysUkUCRQuHJFwDtuqlSkepEMU2uxMb4PR1N-NwtmJQiKXhhbtI9y3tIvi5aeP9vaytUCvaJOzHscD7ohIxXT9spQjhj7JtHtixWTwvu9vBePBLuHifb0p5BEbVXYYZSiG7_s34go63Pb0NF2qeQ37hnuwW6eNDr97OH2oaT0AdT6mgTz4sO5cmwZp30_XoP2ren4WCbKWEOYvkqnj0jcYiwh3pyn-Vos5trpO9ebgEOYDm8mg5Gb_xfBRUqf1i4haFx6AhYyhpILFKKjSFmkPZlGCcXwoBsmPZaglHR8ccm5aPtdGlMRETrsCCp6qdUJOOh3kGGKYTckmsJUBigSrkh0-egrLuvQLECKV5n9RZx9tmYxwRrnsNahVQAY58ydMXJMB_PPEy4J5r9veZwhvwkqFq4O0daabAKMU_b2FdpA1jE73zCn_555BtWOKWaxTYjnUFm_vqsLykbWsmFVfMPuQRonD7Mv6HTlzA |
link.rule.ids | 230,315,733,786,790,870,891,1611,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB2xSNAL-1LWHBC3LI2dpD1WLCpLEQdA3CJ74ogKahCEA3w9YyepKAIkuOTicZT4OZ4Z-80LwJ7IUSZBS7mYRYoSFK5cEfHQzZVKVCeRcW4lNvoXce-an95GtxMQ1bUwlrSPcuDph6GnB3eWW_k0RL_mifmX_YN2zCiLafmTME3fa5h8StLt1ooJ4oNOVY1HKbuPmfb1u5Dk3BowwyhIN4rZP7mistJt5JDGyZKfvM_xPNzUz12STu6910J6-P5F0vHPL7YAc1U86nTL5kWYUHoJlruacvHhm7PvWIao3XpfhtaJKSZ5zJRRnTAlm04XkdyWUZt4cW4GhRgOtNN1DkcGK3B9fHR10HOrXy64SJFZ4RI4RgAoYjFjKLlAIUJFSUvekXmSkQ2P2nHWYRlKSSsjl5yLVtCmay4SGna2ClP6Uat1cDAIkWGOcTsmD4i5jFBkXFE-F2CguGzCXj366VOprJGWJ-IsJbzSCq8meDUyaRUUlM4-pTX_-w67hN_vt1wrIR0Z1TOiCckY2CMDI8I93kIQWjHuCrKNf_fchdneVf88PT-5ONuERmg4M7bWcQumiudXtU1BTyF37BT_ADvlBcI |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwEB7xkBAX3o8urxzQ3vJo7CTNsQIqYBfEYVkhLpE9sUUFNdVuOCy_nrGTVC1iOXDJJZMoyZf4m3G--QxwLDTKLOoqH8tEUYHClS8SHvtaqUzlmUy1s9i4uk7Pb_nlXXI3tdSXE-2jHAbmaRSY4YPTVo5HGLY6sfDm6qSXMqpiuuG41OE8LNI3G-dThbqbXrGJfJQ3HXlUtodYmtC8CkkEtwxLjBJ165r9Pzqqu90mpDQrmJxioMEq3LfXXgtPHoOXSgb4-s7W8Us3twYrTV7q9euQdZhTZgM2-4Zq8tE_77vnlKJuCn4Tuhe2qeS5VNZ9wrZuen1Eoi_rOvHX-z2sxGhovL53OgnYgtvB2a-Tc79ZesFHytAqn0CyRkAJSxlDyQUKESsqXnQudVZSDE96aZmzEqWkEZJLzkU36tFWi4wePduGBfNs1C54GMXIUGPaS4kJUcsERckV1XURRorLDhy3CBTj2mGjqP-Ms4IwKxrMOhC06BRNclCTfkFj_8cHHBGGn59yp4Z1EtS-FR3IZgCfBFgz7tk9BKMz5W5g-_blI49g6eZ0UPy8uP6xB8uxlc64lsd9WKj-vKgDyn0qeeje8jdeQQhC |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunodeficiency+Accelerates+Vitamin+A+Deficiency&rft.jtitle=Current+developments+in+nutrition&rft.au=De%C2%A0Luca%2C+Luigi+M&rft.au=Petrides%2C+Victoria+Hill&rft.au=Darwiche%2C+Nadine&rft.au=Armey%2C+Laura&rft.date=2021-11-01&rft.pub=Oxford+University+Press&rft.eissn=2475-2991&rft.volume=5&rft.issue=11&rft_id=info:doi/10.1093%2Fcdn%2Fnzab129&rft.externalDocID=10.1093%2Fcdn%2Fnzab129 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2475-2991&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2475-2991&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2475-2991&client=summon |