Effect of prehydration solution on hearing threshold after chemotherapy in patients with head and neck cancers: a retrospective study
The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary r...
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Published in | Journal of yeungnam medical science Vol. 40; no. 2; pp. 164 - 171 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Korea (South)
Journal of Yeungnam Medical Science
01.04.2023
Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
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Abstract | The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy.
In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE).
Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis.
Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers. |
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AbstractList | Background: The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy.Methods: In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE).Results: Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis.Conclusion: Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers. BACKGROUNDThe study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. METHODSIn this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE). RESULTSThresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis. CONCLUSIONPrehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers. The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE). Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis. Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers. |
Author | Lee, Kyu-Yup Oh, Minji Jung, Da Jung Ahn, Dongbin Oh, Eunjung Jung, Boseung |
Author_xml | – sequence: 1 givenname: Dongbin surname: Ahn fullname: Ahn, Dongbin organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 2 givenname: Kyu-Yup surname: Lee fullname: Lee, Kyu-Yup organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 3 givenname: Eunjung surname: Oh fullname: Oh, Eunjung organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 4 givenname: Minji surname: Oh fullname: Oh, Minji organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 5 givenname: Boseung surname: Jung fullname: Jung, Boseung organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 6 givenname: Da Jung surname: Jung fullname: Jung, Da Jung organization: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea |
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Cites_doi | 10.1007/s10157-017-1448-z 10.1002/cam4.3529 10.1038/s41467-017-01837-1 10.1016/j.toxlet.2015.06.012 10.1016/j.neuropharm.2017.01.001 10.1038/205698a0 10.1158/1078-0432.ccr-18-2244 10.1155/2016/1809394 10.1016/0006-2952(85)90795-6 10.1523/jneurosci.1544-10.2010 10.1007/s00280-003-0620-1 10.1016/j.fct.2019.111079 10.1055/s-0039-1684041 10.1016/s2352-4642(19)30336-0 10.6064/2012/473829 10.1016/j.ctrv.2006.09.006 10.1016/j.ejpb.2021.03.008 |
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Snippet | The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy.
In this retrospective cohort study, we... Background: The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy.Methods: In this retrospective... BACKGROUNDThe study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. METHODSIn this retrospective... Background The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. Methods In this retrospective... |
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Title | Effect of prehydration solution on hearing threshold after chemotherapy in patients with head and neck cancers: a retrospective study |
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