Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects

• Published in: Brain (London, England : 1878) Vol. 142; no. 4; pp. 1148 - 1160
• Main Authors: Knopman, David S, Lundt, Emily S, Therneau, Terry M, Vemuri, Prashanthi, Lowe, Val J, Kantarci, Kejal, Gunter, Jeffrey L, Senjem, Matthew L, Mielke, Michelle M, Machulda, Mary M, Boeve, Bradley F, Jones, David T, Graff-Radford, Jon, Albertson, Sabrina M, Schwarz, Christopher G, Petersen, Ronald C, Jack, Clifford R
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2019
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - psychology; Amyloid - metabolism; Amyloid beta-Peptides - metabolism; Brain - metabolism; Cognition; Cognitive Dysfunction - psychology; Entorhinal Cortex - pathology; Female; Humans; Magnetic Resonance Imaging; Male; Memory - physiology; Middle Aged; Neuropsychological Tests; Original; Positron-Emission Tomography; tau Proteins - metabolism; Tauopathies - pathology; Temporal Lobe - metabolism; flortaucipir PET; cortical thickness, memory; amyloid PET

Studies involving multiple Alzheimer's disease biomarkers typically rely on dichotomous categorization. Knopman et al. examine how continuous distributions of amyloid PET, tau PET and cortical thickness in medial temporal lobe structures relate to cognition in non-demented persons. Independent...