First evaluation of QuantiFERON-TB Gold Plus performance in contact screening

• Published in: The European respiratory journal Vol. 48; no. 5; pp. 1411 - 1419
• Main Authors: Barcellini, Lucia, Borroni, Emanuele, Brown, James, Brunetti, Enrico, Campisi, Daniela, Castellotti, Paola F., Codecasa, Luigi R., Cugnata, Federica, Di Serio, Clelia, Ferrarese, Maurizio, Goletti, Delia, Lipman, Marc, Rancoita, Paola M.V., Russo, Giulia, Tadolini, Marina, Vanino, Elisa, Cirillo, Daniela M.
• Format: Journal Article
• Language: English
• Published: England 01.11.2016
• Subjects: Adult; Aged; CD4-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - cytology; Contact Tracing - methods; Cross-Sectional Studies; Female; Humans; Incidence; Interferon-gamma; Interferon-gamma Release Tests - methods; Italy; Latent Tuberculosis - diagnosis; Latent Tuberculosis - transmission; Male; Middle Aged; Models, Statistical; Mycobacterium tuberculosis; Tuberculin Test - methods; Tuberculosis, Pulmonary - diagnosis
• ISSN: 0903-1936; 1399-3003
• DOI: 10.1183/13993003.00510-2016

Identifying latently infected individuals is crucial for the elimination of tuberculosis (TB). We evaluated for the first time the performance of a new type of interferon-γ release assay, QuantiFERON-TB Plus (QFT-Plus), which includes an additional antigen tube (TB2), stimulating both CD4 + and CD8...