Decreased Serum Stromal Cell-Derived Factor-1 in Patients with Familial Hypercholesterolemia and Its Strong Correlation with Lipoprotein Subfractions

• Published in: International journal of molecular sciences Vol. 24; no. 20; p. 15308
• Main Authors: Juhász, Lilla, Lőrincz, Hajnalka, Szentpéteri, Anita, Tóth, Nóra, Varga, Éva, Paragh, György, Harangi, Mariann
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: Antilipemic agents; Apolipoproteins; Atherosclerosis; Blood cholesterol; Chemokines; Cholesterol; Enzyme-linked immunosorbent assay; Genetic aspects; High density lipoprotein; Hypercholesterolemia; Hyperlipidemia; Ischemia; Ligands; Lipoproteins; Low density lipoproteins; Males; Medical research; Medicine, Experimental; Physiological aspects; Smooth muscle; Triglycerides; Hungary; United Kingdom

Stromal cell-derived factor-1 (SDF-1) is a chemokine that exerts multifaceted roles in atherosclerosis. However, its association with hyperlipidemia is contradictory. To date, serum SDF-1 and its correlations with lipid fractions and subfractions in heterozygous familial hypercholesterolemia (HeFH)...