Analysis by rotavirus gene 6 reverse transcriptase-polymerase chain reaction assay of rotavirus-positive gastroenteritis cases observed during the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST)

• Published in: Human vaccines & immunotherapeutics Vol. 10; no. 8; pp. 2267 - 2275
• Main Authors: Matson, David O, Vesikari, Timo, Dennehy, Penelope, Dallas, Michael D, Goveia, Michelle G, Itzler, Robbin F, Ciarlet, Max
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.08.2014
• Subjects: Gastroenteritis - prevention & control; Gastroenteritis - virology; Genotype; Humans; Infant; plaque assay; Polymerase Chain Reaction; Research Paper; RNA, Viral - genetics; Rotavirus - classification; Rotavirus - genetics; Rotavirus - isolation & purification; Rotavirus gastroenteritis; rotavirus gene 6 RT-PCR; Rotavirus Infections - prevention & control; Rotavirus Infections - virology; Rotavirus Vaccines - administration & dosage; Rotavirus Vaccines - adverse effects; RV5; vaccine-type; wild-type; RV5; vaccine-type; rotavirus gene 6 RT-PCR; Rotavirus gastroenteritis; wild-type; plaque assay

During the vaccination phase of the Rotavirus Efficacy and Safety Trial (REST), the period between the administration of dose 1 through 13 days after the administration of dose 3, there were more wild-type rotavirus gastroenteritis (RVGE) cases among vaccine recipients compared with placebo recipien...