Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study

• Published in: Psychological medicine Vol. 50; no. 11; pp. 1884 - 1897
• Main Authors: van Os, Jim, Pries, Lotta-Katrin, Delespaul, Philippe, Kenis, Gunter, Luykx, Jurjen J., Lin, Bochao D., Richards, Alexander L., Akdede, Berna, Binbay, Tolga, Altınyazar, Vesile, Yalınçetin, Berna, Gümüş-Akay, Güvem, Cihan, Burçin, Soygür, Haldun, Ulaş, Halis, Cankurtaran, Eylem Şahin, Kaymak, Semra Ulusoy, Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Bernardo, Miguel, Cabrera, Bibiana, Bobes, Julio, Saiz, Pilar A., García-Portilla, María Paz, Sanjuan, Julio, Aguilar, Eduardo J., Santos, José Luis, Jiménez-López, Estela, Arrojo, Manuel, Carracedo, Angel, López, Gonzalo, González-Peñas, Javier, Parellada, Mara, Maric, Nadja P., Atbaşoğlu, Cem, Ucok, Alp, Alptekin, Köksal, Saka, Meram Can, Arango, Celso, O'Donovan, Michael, Rutten, Bart P. F., Guloksuz, Sinan
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2020
• Subjects: Bias; Cognition & reasoning; Cognitive ability; Cognitive bias; Consortia; Discovery; Environmental liability; Genetic susceptibility; Genomics; Jumping; Medical prognosis; Mental disorders; Neurosciences; Online instruction; Original Articles; Phenotypes; Population distribution; Psychopathology; Psychosis; Relatives; Replication; Schizophrenia; Siblings; Cognition; genetics; schizophrenia; schizotypy

First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. We conducted, using two different samples for discovery (n = 336 controls and 649 siblings of patients with psychotic disorder) and re...