Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study

First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. We conducted, using two different samples for discovery (n = 336 controls and 649 siblings of patients with psychotic disorder) and re...

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Published inPsychological medicine Vol. 50; no. 11; pp. 1884 - 1897
Main Authors van Os, Jim, Pries, Lotta-Katrin, Delespaul, Philippe, Kenis, Gunter, Luykx, Jurjen J., Lin, Bochao D., Richards, Alexander L., Akdede, Berna, Binbay, Tolga, Altınyazar, Vesile, Yalınçetin, Berna, Gümüş-Akay, Güvem, Cihan, Burçin, Soygür, Haldun, Ulaş, Halis, Cankurtaran, Eylem Şahin, Kaymak, Semra Ulusoy, Mihaljevic, Marina M., Petrovic, Sanja Andric, Mirjanic, Tijana, Bernardo, Miguel, Cabrera, Bibiana, Bobes, Julio, Saiz, Pilar A., García-Portilla, María Paz, Sanjuan, Julio, Aguilar, Eduardo J., Santos, José Luis, Jiménez-López, Estela, Arrojo, Manuel, Carracedo, Angel, López, Gonzalo, González-Peñas, Javier, Parellada, Mara, Maric, Nadja P., Atbaşoğlu, Cem, Ucok, Alp, Alptekin, Köksal, Saka, Meram Can, Arango, Celso, O'Donovan, Michael, Rutten, Bart P. F., Guloksuz, Sinan
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Published Cambridge, UK Cambridge University Press 01.08.2020
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Abstract First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. We conducted, using two different samples for discovery (n = 336 controls and 649 siblings of patients with psychotic disorder) and replication (n = 1208 controls and 1106 siblings), an analysis of association between PRS on the one hand and psychopathological and cognitive intermediate phenotypes of schizophrenia on the other in a sample at average genetic risk (healthy controls) and a sample at higher than average risk (healthy siblings of patients). Two subthreshold psychosis phenotypes, as well as a standardised measure of cognitive ability, based on a short version of the WAIS-III short form, were used. In addition, a measure of jumping to conclusion bias (replication sample only) was tested for association with PRS. In both discovery and replication sample, evidence for an association between PRS and subthreshold psychosis phenotypes was observed in the relatives of patients, whereas in the controls no association was observed. Jumping to conclusion bias was similarly only associated with PRS in the sibling group. Cognitive ability was weakly negatively and non-significantly associated with PRS in both the sibling and the control group. The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.
AbstractList BACKGROUNDFirst-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. METHODSWe conducted, using two different samples for discovery (n = 336 controls and 649 siblings of patients with psychotic disorder) and replication (n = 1208 controls and 1106 siblings), an analysis of association between PRS on the one hand and psychopathological and cognitive intermediate phenotypes of schizophrenia on the other in a sample at average genetic risk (healthy controls) and a sample at higher than average risk (healthy siblings of patients). Two subthreshold psychosis phenotypes, as well as a standardised measure of cognitive ability, based on a short version of the WAIS-III short form, were used. In addition, a measure of jumping to conclusion bias (replication sample only) was tested for association with PRS. RESULTSIn both discovery and replication sample, evidence for an association between PRS and subthreshold psychosis phenotypes was observed in the relatives of patients, whereas in the controls no association was observed. Jumping to conclusion bias was similarly only associated with PRS in the sibling group. Cognitive ability was weakly negatively and non-significantly associated with PRS in both the sibling and the control group. CONCLUSIONSThe degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.
First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. We conducted, using two different samples for discovery (n = 336 controls and 649 siblings of patients with psychotic disorder) and replication (n = 1208 controls and 1106 siblings), an analysis of association between PRS on the one hand and psychopathological and cognitive intermediate phenotypes of schizophrenia on the other in a sample at average genetic risk (healthy controls) and a sample at higher than average risk (healthy siblings of patients). Two subthreshold psychosis phenotypes, as well as a standardised measure of cognitive ability, based on a short version of the WAIS-III short form, were used. In addition, a measure of jumping to conclusion bias (replication sample only) was tested for association with PRS. In both discovery and replication sample, evidence for an association between PRS and subthreshold psychosis phenotypes was observed in the relatives of patients, whereas in the controls no association was observed. Jumping to conclusion bias was similarly only associated with PRS in the sibling group. Cognitive ability was weakly negatively and non-significantly associated with PRS in both the sibling and the control group. The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.
Author Bobes, Julio
O'Donovan, Michael
Altınyazar, Vesile
Alptekin, Köksal
Akdede, Berna
Binbay, Tolga
Soygür, Haldun
Kaymak, Semra Ulusoy
Arrojo, Manuel
Luykx, Jurjen J.
Guloksuz, Sinan
Richards, Alexander L.
Aguilar, Eduardo J.
Pries, Lotta-Katrin
Sanjuan, Julio
Ulaş, Halis
González-Peñas, Javier
Santos, José Luis
Cihan, Burçin
Arango, Celso
López, Gonzalo
Saiz, Pilar A.
Carracedo, Angel
van Os, Jim
García-Portilla, María Paz
Parellada, Mara
Mihaljevic, Marina M.
Rutten, Bart P. F.
Kenis, Gunter
Jiménez-López, Estela
Ucok, Alp
Cankurtaran, Eylem Şahin
Cabrera, Bibiana
Mirjanic, Tijana
Delespaul, Philippe
Bernardo, Miguel
Yalınçetin, Berna
Maric, Nadja P.
Gümüş-Akay, Güvem
Atbaşoğlu, Cem
Saka, Meram Can
Lin, Bochao D.
Petrovic, Sanja Andric
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31414981$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1080/13546805.2012.731390
10.1086/519795
10.1038/nature09563
10.1093/schbul/sbz061
10.1038/mp.2013.166
10.1093/schbul/15.4.559
10.1001/archgenpsychiatry.2010.132
10.1016/j.ajhg.2008.06.005
10.1038/mp.2012.105
10.1037/h0023653
10.1192/S0007125000292581
10.1016/S0920-9964(00)00017-7
10.1016/j.schres.2008.07.015
10.1001/archpsyc.1982.04290070020005
10.1176/appi.ajp.2011.10101531
10.1017/S0033291717000915
10.1093/schbul/sbx074
10.1001/jamapsychiatry.2015.0346
10.1093/schbul/sbv168
10.1038/nn.4040
10.1093/schbul/sbu069
10.1002/ajmg.b.32323
10.1038/ng.3679
10.1093/oxfordjournals.schbul.a033482
10.1002/mpr.1352
10.1016/0010-440X(93)90047-8
10.1016/S0140-6736(13)62036-X
10.1093/schbul/sbj021
10.1038/nature13595
10.1097/00001648-199001000-00010
10.1111/j.1600-0447.2005.00741.x
10.1038/ng.3656
10.1002/wps.20629
10.1016/S2215-0366(16)30406-0
10.1017/S0033291717001775
10.1038/mp.2014.94
10.1093/schbul/sbx031
10.1001/jamapsychiatry.2015.3058
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References Phillips, Edwards 1966; 72
Andreasen 1982; 39
Richards, Pardinas, Frizzati, Tansey, Lynham, Holmans, Legge, Savage, Agartz, Andreassen, Blokland, Corvin, Cosgrove, Degenhardt, Djurovic, Espeseth, Ferraro, Gayer-Anderson, Giegling, van Haren, Hartmann, Hubert, Jonsson, Konte, Lennertz, Olde Loohuis, Melle, Morgan, Morris, Murray, Nyman, Ophoff, Investigators, van Os, Group, Petryshen, Quattrone, Rietschel, Rujescu, Rutten, Streit, Strohmaier, Sullivan, Sundet, Wagner, Escott-Price, Owen, Donohoe, O'Donovan, Walters 2019
Guloksuz, van Os 2018; 48
Korver, Quee, Boos, Simons, de Haan 2012; 21
Selten, Sijben, van den Bosch, Omloo Visser, Warmerdam 1993; 34
Hubbard, Tansey, Rai, Jones, Ripke, Chambert, Moran, McCarroll, Linden, Owen, O'Donovan, Walters, Zammit 2016; 42
van Os, Kenis, Rutten 2010; 468
Hatzimanolis, Bhatnagar, Moes, Wang, Roussos, Bitsios, Stefanis, Pulver, Arking, Smyrnis, Stefanis, Avramopoulos 2015; 168B
Nivard, Gage, Hottenga, van Beijsterveldt, Abdellaoui, Bartels, Baselmans, Ligthart, Pourcain, Boomsma, Munafo, Middeldorp 2017; 43
Pries, Klingenberg, Menne-Lothmann, Decoster, van Winkel, Collip, Delespaul, De Hert, Derom, Thiery, Jacobs, Wichers, Cinar, Lin, Luykx, Rutten, van Os, Guloksuz 2019
Heins, Simons, Lataster, Pfeifer, Versmissen, Lardinois, Marcelis, Delespaul, Krabbendam, van Os, Myin-Germeys 2011; 168
Price, Weale, Patterson, Myers, Need, Shianna, Ge, Rotter, Torres, Taylor, Goldstein, Reich 2008; 83
Velthorst, Levine, Henquet, de Haan, van Os, Myin-Germeys, Reichenberg 2013; 18
Kendler, Lieberman, Walsh 1989; 15
van Os, Rutten, Myin-Germeys, Delespaul, Viechtbauer, van Zelst, Bruggeman, Reininghaus, Morgan, Murray, Di Forti, McGuire, Valmaggia, Kempton, Gayer-Anderson, Hubbard, Beards, Stilo, Onyejiaka, Bourque, Modinos, Tognin, Calem, O'Donovan, Owen, Holmans, Williams, Craddock, Richards, Humphreys, Meyer-Lindenberg, Leweke, Tost, Akdeniz, Rohleder, Bumb, Schwarz, Alptekin, Ucok, Saka, Atbasoglu, Guloksuz, Gumus-Akay, Cihan, Karadag, Soygur, Cankurtaran, Ulusoy, Akdede, Binbay, Ayer, Noyan, Karadayi, Akturan, Ulas, Arango, Parellada, Bernardo, Sanjuan, Bobes, Arrojo, Santos, Cuadrado, Rodriguez Solano, Carracedo, Garcia Bernardo, Roldan, Lopez, Cabrera, Cruz, Diaz Mesa, Pouso, Jimenez, Sanchez, Rapado, Gonzalez, Martinez, Sanchez, Olmeda, de Haan, Velthorst, van der Gaag, Selten, van Dam, van der Ven, van der Meer, Messchaert, Kraan, Burger, Leboyer, Szoke, Schurhoff, Llorca, Jamain, Tortelli, Frijda, Vilain, Galliot, Baudin, Ferchiou, Richard, Bulzacka, Charpeaud, Tronche, De Hert, van Winkel, Decoster, Derom, Thiery, Stefanis, Sachs, Aschauer, Lasser, Winklbaur, Schlogelhofer, Riecher-Rossler, Borgwardt, Walter, Harrisberger, Smieskova, Rapp, Ittig, Soguel-dit-Piquard, Studerus, Klosterkotter, Ruhrmann, Paruch, Julkowski, Hilboll, Sham, Cherny, Chen, Campbell, Li, Romeo-Casabona, Emaldi Cirion, Urruela Mora, Jones, Kirkbride, Cannon, Rujescu, Tarricone, Berardi, Bonora, Seri, Marcacci, Chiri, Chierzi, Storbini, Braca, Minenna, Donegani, Fioritti, La Barbera, La Cascia, Mule, Sideli, Sartorio, Ferraro, Tripoli, Seminerio, Marinaro, McGorry, Nelson, Amminger, Pantelis, Menezes, Del-Ben, Gallo Tenan, Shuhama, Ruggeri, Tosato, Lasalvia, Bonetto, Ira, Nordentoft, Krebs, Barrantes-Vidal, Cristobal, Kwapil, Brietzke, Bressan, Gadelha, Maric, Andric, Mihaljevic, Mirjanic 2014; 40
2014; 511
Konings, Bak, Hanssen, van Os, Krabbendam 2006; 114
Purcell, Neale, Todd-Brown, Thomas, Ferreira, Bender, Maller, Sklar, de Bakker, Daly, Sham 2007; 81
Addington, Addington, Maticka-Tyndale 1993; 22
van Os, van der Steen, Islam, Guloksuz, Rutten, Simons, Investigators 2017; 47
McGue, Gottesman, Rao 1983; 35
McLean, Mattiske, Balzan 2017; 43
Kapur, Phillips, Insel 2012; 17
Loh, Danecek, Palamara, Fuchsberger, AR, KF, Schoenherr, Forer, McCarthy, Abecasis, Durbin, LP 2016; 48
Van Dael, Versmissen, Janssen, Myin-Germeys, van Os, Krabbendam 2006; 32
Das, Forer, Schonherr, Sidore, Locke, Kwong, Vrieze, Chew, Levy, McGue, Schlessinger, Stambolian, Loh, Iacono, Swaroop, Scott, Cucca, Kronenberg, Boehnke, Abecasis, Fuchsberger 2016; 48
Jones, Stergiakouli, Tansey, Hubbard, Heron, Cannon, Holmans, Lewis, Linden, Jones, Davey Smith, O'Donovan, Owen, Walters, Zammit 2016; 73
Vollema, Ormel 2000; 26
Mistry, Harrison, Smith, Escott-Price, Zammit 2017
2011; 68
Blyler, Gold, Iannone, Buchanan 2000; 46
Hatzimanolis, Avramopoulos, Arking, Moes, Bhatnagar, Lencz, Malhotra, Giakoumaki, Roussos, Smyrnis, Bitsios, Stefanis 2018; 44
Guloksuz, Pries, Delespaul, Kenis, Luykx, Lin, Richards, Akdede, Binbay, Altinyazar, Yalincetin, Gumus-Akay, Cihan, Soygur, Ulas, Cankurtaran, Kaymak, Mihaljevic, Petrovic, Mirjanic, Bernardo, Cabrera, Bobes, Saiz, Garcia-Portilla, Sanjuan, Aguilar, Santos, Jimenez-Lopez, Arrojo, Carracedo, Lopez, Gonzalez-Penas, Parellada, Maric, Atbasog Lu, Ucok, Alptekin, Saka, Genetic, Arango, O'Donovan, Rutten, van Os 2019; 18
Rothman 1990; 1
Smith, Barch, Wolf, Mamah, Csernansky 2008; 106
Kendler 2015; 20
Howes, Murray 2014; 383
Lencz, Knowles, Davies, Guha, Liewald, Starr, Djurovic, Melle, Sundet, Christoforou, Reinvang, Mukherjee, DeRosse, Lundervold, Steen, John, Espeseth, Raikkonen, Widen, Palotie, Eriksson, Giegling, Konte, Ikeda, Roussos, Giakoumaki, Burdick, Payton, Ollier, Horan, Donohoe, Morris, Corvin, Gill, Pendleton, Iwata, Darvasi, Bitsios, Rujescu, Lahti, Hellard, Keller, Andreassen, Deary, Glahn, Malhotra 2014; 19
Riglin, Collishaw, Richards, Thapar, Maughan, O'Donovan, Thapar 2017; 4
Agerbo, Sullivan, Vilhjalmsson, Pedersen, Mors, Borglum, Hougaard, Hollegaard, Meier, Mattheisen, Ripke, Wray, Mortensen 2015; 72
Power, Steinberg, Bjornsdottir, Rietveld, Abdellaoui, Nivard, Johannesson, Galesloot, Hottenga, Willemsen, Cesarini, Benjamin, Magnusson, Ullen, Tiemeier, Hofman, van Rooij, Walters, Sigurdsson, Thorgeirsson, Ingason, Helgason, Kong, Kiemeney, Koellinger, Boomsma, Gudbjartsson, Stefansson, Stefansson 2015; 18
Wechsler (S003329171900196X_ref44) 1997
S003329171900196X_ref22
S003329171900196X_ref42
S003329171900196X_ref20
McGue (S003329171900196X_ref23) 1983; 35
S003329171900196X_ref43
S003329171900196X_ref21
S003329171900196X_ref40
S003329171900196X_ref41
S003329171900196X_ref28
S003329171900196X_ref29
S003329171900196X_ref26
(S003329171900196X_ref38) 2017
S003329171900196X_ref27
Pries (S003329171900196X_ref30) 2019
Wing (S003329171900196X_ref45) 1974
S003329171900196X_ref1
Mistry (S003329171900196X_ref25) 2017
S003329171900196X_ref2
S003329171900196X_ref3
S003329171900196X_ref4
S003329171900196X_ref5
S003329171900196X_ref11
S003329171900196X_ref33
S003329171900196X_ref34
S003329171900196X_ref12
S003329171900196X_ref7
S003329171900196X_ref8
S003329171900196X_ref31
S003329171900196X_ref9
S003329171900196X_ref10
S003329171900196X_ref32
McLean (S003329171900196X_ref24) 2017; 43
S003329171900196X_ref19
S003329171900196X_ref17
S003329171900196X_ref39
van Os (S003329171900196X_ref6) 2014; 40
S003329171900196X_ref18
S003329171900196X_ref15
S003329171900196X_ref37
S003329171900196X_ref16
S003329171900196X_ref13
S003329171900196X_ref35
S003329171900196X_ref36
S003329171900196X_ref14
References_xml – volume: 39
  start-page: 784
  year: 1982
  end-page: 788
  article-title: Negative symptoms in schizophrenia. Definition and reliability
  publication-title: Archives of General Psychiatry
  contributor:
    fullname: Andreasen
– volume: 114
  start-page: 55
  year: 2006
  end-page: 61
  article-title: Validity and reliability of the CAPE: a self-report instrument for the measurement of psychotic experiences in the general population
  publication-title: Acta Psychiatrica Scandinavica
  contributor:
    fullname: Krabbendam
– volume: 43
  start-page: 1197
  year: 2017
  end-page: 1207
  article-title: Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Middeldorp
– volume: 48
  start-page: 1443
  year: 2016
  end-page: 1448
  article-title: Reference-based phasing using the Haplotype Reference Consortium panel
  publication-title: Nature Genetics
  contributor:
    fullname: LP
– volume: 72
  start-page: 635
  year: 2015
  end-page: 641
  article-title: Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysis
  publication-title: JAMA Psychiatry
  contributor:
    fullname: Mortensen
– volume: 168B
  start-page: 392
  year: 2015
  end-page: 401
  article-title: Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood
  publication-title: American Journal of Medical Genetics B – Neuropsychiatric Genetics
  contributor:
    fullname: Avramopoulos
– volume: 18
  start-page: 574
  year: 2013
  end-page: 593
  article-title: To cut a short test even shorter: reliability and validity of a brief assessment of intellectual ability in schizophrenia – a control-case family study
  publication-title: Cognitive Neuropsychiatry
  contributor:
    fullname: Reichenberg
– volume: 468
  start-page: 203
  year: 2010
  end-page: 212
  article-title: The environment and schizophrenia
  publication-title: Nature
  contributor:
    fullname: Rutten
– volume: 34
  start-page: 192
  year: 1993
  end-page: 197
  article-title: The subjective experience of negative symptoms: a self-rating scale
  publication-title: Comprehensive Psychiatry
  contributor:
    fullname: Warmerdam
– volume: 22
  start-page: 39
  year: 1993
  end-page: 44
  article-title: Assessing depression in schizophrenia: the Calgary Depression Scale
  publication-title: British Journal of Psychiatry Supplement
  contributor:
    fullname: Maticka-Tyndale
– volume: 18
  start-page: 953
  year: 2015
  end-page: 955
  article-title: Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
  publication-title: Nature Neuroscience
  contributor:
    fullname: Stefansson
– volume: 383
  start-page: 1677
  year: 2014
  end-page: 1687
  article-title: Schizophrenia: an integrated sociodevelopmental-cognitive model
  publication-title: Lancet
  contributor:
    fullname: Murray
– volume: 44
  start-page: 338
  year: 2018
  end-page: 347
  article-title: Stress-dependent association between polygenic risk for schizophrenia and schizotypal traits in young army recruits
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Stefanis
– year: 2017
  article-title: The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: systematic review
  publication-title: Schizophrenia Research
  contributor:
    fullname: Zammit
– year: 2019
  article-title: The relationship between polygenic risk scores and cognition in schizophrenia
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Walters
– volume: 35
  start-page: 1161
  year: 1983
  end-page: 1178
  article-title: The transmission of schizophrenia under a multifactorial threshold model
  publication-title: American Journal of Human Genetics
  contributor:
    fullname: Rao
– volume: 4
  start-page: 57
  year: 2017
  end-page: 62
  article-title: Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study
  publication-title: The Lancet Psychiatry
  contributor:
    fullname: Thapar
– volume: 73
  start-page: 221
  year: 2016
  end-page: 228
  article-title: Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population
  publication-title: JAMA Psychiatry
  contributor:
    fullname: Zammit
– volume: 81
  start-page: 559
  year: 2007
  end-page: 575
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: American Journal of Human Genetics
  contributor:
    fullname: Sham
– volume: 68
  start-page: 138
  year: 2011
  end-page: 147
  article-title: Evidence that familial liability for psychosis is expressed as differential sensitivity to cannabis: an analysis of patient-sibling and sibling-control pairs
  publication-title: Archives of General Psychiatry
– year: 2019
  article-title: Interaction between polygenic liability for schizophrenia and childhood adversity influences daily-life emotional dysregulation and subtle psychosis expression
  publication-title: Submitted Manuscript
  contributor:
    fullname: Guloksuz
– volume: 42
  start-page: 832
  year: 2016
  end-page: 842
  article-title: Evidence of common genetic overlap between schizophrenia and cognition
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Zammit
– volume: 21
  start-page: 205
  year: 2012
  end-page: 221
  article-title: Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene–environment interaction: objectives, sample characteristics, recruitment and assessment methods
  publication-title: International Journal of Methods in Psychiatric Research
  contributor:
    fullname: de Haan
– volume: 18
  start-page: 173
  year: 2019
  end-page: 182
  article-title: Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
  publication-title: World Psychiatry
  contributor:
    fullname: van Os
– volume: 168
  start-page: 1286
  year: 2011
  end-page: 1294
  article-title: Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma
  publication-title: American Journal of Psychiatry
  contributor:
    fullname: Myin-Germeys
– volume: 26
  start-page: 619
  year: 2000
  end-page: 629
  article-title: The reliability of the structured interview for schizotypy-revised
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Ormel
– volume: 19
  start-page: 168
  year: 2014
  end-page: 174
  article-title: Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
  publication-title: Molecular Psychiatry
  contributor:
    fullname: Malhotra
– volume: 106
  start-page: 294
  year: 2008
  end-page: 299
  article-title: Elevated rates of substance use disorders in non-psychotic siblings of individuals with schizophrenia
  publication-title: Schizophrenia Research
  contributor:
    fullname: Csernansky
– volume: 46
  start-page: 209
  year: 2000
  end-page: 215
  article-title: Short form of the WAIS-III for use with patients with schizophrenia
  publication-title: Schizophrenia Research
  contributor:
    fullname: Buchanan
– volume: 32
  start-page: 341
  year: 2006
  end-page: 351
  article-title: Data gathering: biased in psychosis?
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Krabbendam
– volume: 20
  start-page: 77
  year: 2015
  end-page: 83
  article-title: A joint history of the nature of genetic variation and the nature of schizophrenia
  publication-title: Molecular Psychiatry
  contributor:
    fullname: Kendler
– volume: 72
  start-page: 346
  year: 1966
  end-page: 354
  article-title: Conservatism in a simple probability inference task
  publication-title: Journal of Experimental Psychology
  contributor:
    fullname: Edwards
– volume: 1
  start-page: 43
  year: 1990
  end-page: 46
  article-title: No adjustments are needed for multiple comparisons
  publication-title: Epidemiology
  contributor:
    fullname: Rothman
– volume: 48
  start-page: 1284
  year: 2016
  end-page: 1287
  article-title: Next-generation genotype imputation service and methods
  publication-title: Nature Genetics
  contributor:
    fullname: Fuchsberger
– volume: 17
  start-page: 1174
  year: 2012
  end-page: 1179
  article-title: Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?
  publication-title: Molecular Psychiatry
  contributor:
    fullname: Insel
– volume: 511
  start-page: 421
  year: 2014
  end-page: 427
  article-title: Biological insights from 108 schizophrenia-associated genetic loci
  publication-title: Nature
– volume: 47
  start-page: 2421
  year: 2017
  end-page: 2437
  article-title: Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
  publication-title: Psychological Medicine
  contributor:
    fullname: Investigators
– volume: 48
  start-page: 229
  year: 2018
  end-page: 244
  article-title: The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum
  publication-title: Psychological Medicine
  contributor:
    fullname: van Os
– volume: 40
  start-page: 729
  year: 2014
  end-page: 736
  article-title: Identifying gene–environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Mirjanic
– volume: 43
  start-page: 344
  year: 2017
  end-page: 354
  article-title: Association of the jumping to conclusions and evidence integration biases with delusions in psychosis: a detailed meta-analysis
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Balzan
– volume: 83
  start-page: 132
  year: 2008
  end-page: 135
  article-title: Long-range LD can confound genome scans in admixed populations
  publication-title: American Journal of Human Genetics
  contributor:
    fullname: Reich
– volume: 15
  start-page: 559
  year: 1989
  end-page: 571
  article-title: The structured interview for schizotypy (SIS): a preliminary report
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: Walsh
– ident: S003329171900196X_ref42
  doi: 10.1080/13546805.2012.731390
– ident: S003329171900196X_ref31
  doi: 10.1086/519795
– ident: S003329171900196X_ref40
  doi: 10.1038/nature09563
– volume-title: The Measurement and Classification of Psychiatric Symptoms
  year: 1974
  ident: S003329171900196X_ref45
  contributor:
    fullname: Wing
– ident: S003329171900196X_ref32
  doi: 10.1093/schbul/sbz061
– ident: S003329171900196X_ref21
  doi: 10.1038/mp.2013.166
– ident: S003329171900196X_ref18
  doi: 10.1093/schbul/15.4.559
– year: 2017
  ident: S003329171900196X_ref25
  article-title: The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: systematic review
  publication-title: Schizophrenia Research
  contributor:
    fullname: Mistry
– ident: S003329171900196X_ref7
  doi: 10.1001/archgenpsychiatry.2010.132
– volume-title: STATA Statistical Software: Release 15
  year: 2017
  ident: S003329171900196X_ref38
– ident: S003329171900196X_ref29
  doi: 10.1016/j.ajhg.2008.06.005
– ident: S003329171900196X_ref16
  doi: 10.1038/mp.2012.105
– ident: S003329171900196X_ref27
  doi: 10.1037/h0023653
– ident: S003329171900196X_ref1
  doi: 10.1192/S0007125000292581
– ident: S003329171900196X_ref4
  doi: 10.1016/S0920-9964(00)00017-7
– ident: S003329171900196X_ref37
  doi: 10.1016/j.schres.2008.07.015
– volume: 43
  start-page: 344
  year: 2017
  ident: S003329171900196X_ref24
  article-title: Association of the jumping to conclusions and evidence integration biases with delusions in psychosis: a detailed meta-analysis
  publication-title: Schizophrenia Bulletin
  contributor:
    fullname: McLean
– ident: S003329171900196X_ref3
  doi: 10.1001/archpsyc.1982.04290070020005
– ident: S003329171900196X_ref12
  doi: 10.1176/appi.ajp.2011.10101531
– ident: S003329171900196X_ref41
  doi: 10.1017/S0033291717000915
– ident: S003329171900196X_ref11
  doi: 10.1093/schbul/sbx074
– volume: 35
  start-page: 1161
  year: 1983
  ident: S003329171900196X_ref23
  article-title: The transmission of schizophrenia under a multifactorial threshold model
  publication-title: American Journal of Human Genetics
  contributor:
    fullname: McGue
– ident: S003329171900196X_ref2
  doi: 10.1001/jamapsychiatry.2015.0346
– ident: S003329171900196X_ref14
  doi: 10.1093/schbul/sbv168
– ident: S003329171900196X_ref28
  doi: 10.1038/nn.4040
– volume: 40
  start-page: 729
  year: 2014
  ident: S003329171900196X_ref6
  article-title: Identifying gene–environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations
  publication-title: Schizophrenia Bulletin
  doi: 10.1093/schbul/sbu069
  contributor:
    fullname: van Os
– ident: S003329171900196X_ref10
  doi: 10.1002/ajmg.b.32323
– ident: S003329171900196X_ref22
  doi: 10.1038/ng.3679
– ident: S003329171900196X_ref43
  doi: 10.1093/oxfordjournals.schbul.a033482
– ident: S003329171900196X_ref20
  doi: 10.1002/mpr.1352
– ident: S003329171900196X_ref36
  doi: 10.1016/0010-440X(93)90047-8
– ident: S003329171900196X_ref13
  doi: 10.1016/S0140-6736(13)62036-X
– ident: S003329171900196X_ref39
  doi: 10.1093/schbul/sbj021
– volume-title: WAIS-III: Wechsler Adult Intelligence Scale. Administration and Scoring Manual
  year: 1997
  ident: S003329171900196X_ref44
  contributor:
    fullname: Wechsler
– ident: S003329171900196X_ref35
  doi: 10.1038/nature13595
– ident: S003329171900196X_ref34
  doi: 10.1097/00001648-199001000-00010
– ident: S003329171900196X_ref19
  doi: 10.1111/j.1600-0447.2005.00741.x
– ident: S003329171900196X_ref5
  doi: 10.1038/ng.3656
– ident: S003329171900196X_ref9
  doi: 10.1002/wps.20629
– ident: S003329171900196X_ref33
  doi: 10.1016/S2215-0366(16)30406-0
– ident: S003329171900196X_ref8
  doi: 10.1017/S0033291717001775
– ident: S003329171900196X_ref17
  doi: 10.1038/mp.2014.94
– ident: S003329171900196X_ref26
  doi: 10.1093/schbul/sbx031
– ident: S003329171900196X_ref15
  doi: 10.1001/jamapsychiatry.2015.3058
– year: 2019
  ident: S003329171900196X_ref30
  article-title: Interaction between polygenic liability for schizophrenia and childhood adversity influences daily-life emotional dysregulation and subtle psychosis expression
  publication-title: Submitted Manuscript
  contributor:
    fullname: Pries
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Snippet First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate...
BackgroundFirst-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of...
BACKGROUNDFirst-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of...
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SubjectTerms Bias
Cognition & reasoning
Cognitive ability
Cognitive bias
Consortia
Discovery
Environmental liability
Genetic susceptibility
Genomics
Jumping
Medical prognosis
Mental disorders
Neurosciences
Online instruction
Original Articles
Phenotypes
Population distribution
Psychopathology
Psychosis
Relatives
Replication
Schizophrenia
Siblings
Title Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
URI https://www.cambridge.org/core/product/identifier/S003329171900196X/type/journal_article
https://www.ncbi.nlm.nih.gov/pubmed/31414981
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https://search.proquest.com/docview/2273754645
Volume 50
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