Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test

• Published in: Behavioural brain research Vol. 240; pp. 91 - 94
• Main Authors: Cagni, Priscila, Barros, Marilia
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.03.2013; Elsevier
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Anxiety; Anxiolytics; Behavior; Behavior, Animal - drug effects; Behavior, Animal - physiology; Behavioral psychophysiology; Benzoxazines - pharmacology; Biological and medical sciences; Callithrix; Cannabinoid Receptor Agonists - pharmacology; Cannabinoid Receptor Antagonists - pharmacology; CB1 receptor; Data processing; Emotional behavior; Emotions; Exploration; Exploratory Behavior - drug effects; Exploratory Behavior - physiology; Fundamental and applied biological sciences. Psychology; Locomotion; Marmoset; Morpholines - pharmacology; Motor Activity - drug effects; Motor Activity - physiology; Naphthalenes - pharmacology; Open-field; Open-field behavior; Piperidines - pharmacology; Primates; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Pyrazoles - pharmacology; Receptor density; Receptor, Cannabinoid, CB1 - agonists; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - physiology; Vocalization behavior; Open-field; Marmoset; Anxiety; Behavior; CB1 receptor; CB1 cannabinoid receptor; Affect affectivity; Ligand; Monkey; Open field behavior; Vertebrata; Mammalia; Animal; Cannabinoid receptor; Primates

► Single brief exposure to open-field induced anxiety-related behaviors in marmosets. ► Cannabinoid type 1 receptor ligands attenuated anxiety-related behaviors in marmosets. ► Endocannabinoid system exerts complex role on anxiety in nonhuman primates. Cannabinoid type 1 receptors (CB1r) are an impo...