Adaptive laboratory evolution of Rhodosporidium toruloides to inhibitors derived from lignocellulosic biomass and genetic variations behind evolution

• Published in: Bioresource technology Vol. 333; p. 125171
• Main Authors: Liu, Zhijia, Radi, Mohammad, Mohamed, Elsayed T.T., Feist, Adam M., Dragone, Giuliano, Mussatto, Solange I.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2021
• Subjects: Adaptive laboratory evolution; Hydrolysate; Inhibitors; Rhodosporidium toruloides; Tolerance; Tolerance; Inhibitors; Hydrolysate; Adaptive laboratory evolution; Rhodosporidium toruloides

•A strategy of adaptive laboratory evolution in hydrolysate-based medium was developed.•Evolved strains of Rhodosporidium toruloides presented better tolerance to inhibitors.•The strain’s ability to accumulate lipids and produce carotenoids was also improved.•Whole genome sequencing revealed toleran...