Inhibitors of Glyceraldehyde 3-Phosphate Dehydrogenase and Unexpected Effects of Its Reduced Activity

• Published in: Biochemistry (Moscow) Vol. 84; no. 11; pp. 1268 - 1279
• Main Authors: Muronetz, V. I., Melnikova, A. K., Barinova, K. V., Schmalhausen, E. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.11.2019; Springer; Springer Nature B.V
• Subjects: Analysis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Control; Deactivation; Dehydrogenase; Dehydrogenases; Enzyme inhibitors; Enzymes; Glutathione; Glyceraldehyde; Glyceraldehyde 3-phosphate; Glyceraldehyde 3-phosphate dehydrogenase; Glycolysis; Inactivation; Inhibitors; Life Sciences; Mammalian cells; Metabolic pathways; Microbiology; Nature conservation; Oxidation; Pentose; Pentose phosphate pathway; Phosphorylation; Reactive oxygen species; Review; Tuberculosis; United States; glycation; oxidation; inhibitors; sulfhydryl group; glycolysis; glyceraldehyde 3-phosphate dehydrogenase

The review describes the use of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitors to study the enzyme and to suppress its activity in various cell types. The main problem of selective GAPDH inhibition is a highly conserved nature of the enzyme active site and, especially, Cys150 environmen...