Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577
We report the design and synthesis of a novel class of N,N′-disubstituted aroylguanidine-based lactam derivatives as potent and orally active FXa inhibitors. The structure–activity relationships (SAR) investigation led to the discovery of the nicotinoyl guanidine 22 as a potent FXa inhibitor (FXa IC...
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Published in | Bioorganic & medicinal chemistry letters Vol. 19; no. 24; pp. 6882 - 6889 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Ltd
15.12.2009
Elsevier |
Subjects | |
Online Access | Get full text |
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