The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine

• Published in: American journal of kidney diseases Vol. 47; no. 1; p. 42
• Main Authors: Yilmaz, Mahmut Ilker, Saglam, Mutlu, Caglar, Kayser, Cakir, Erdinc, Sonmez, Alper, Ozgurtas, Taner, Aydin, Ahmet, Eyileten, Tayfun, Ozcan, Omer, Acikel, Cengizhan, Tasar, Mustafa, Genctoy, Gultekin, Erbil, Kemal, Vural, Abdulgaffar, Zoccali, Carmine
• Format: Journal Article
• Language: English
• Published: United States 01.01.2006
• Subjects: Adult; Arginine - analogs & derivatives; Arginine - physiology; Brachial Artery - physiopathology; Cardiovascular Diseases - etiology; Chronic Disease; Copper - blood; Endothelium, Vascular - physiopathology; Erythrocytes - enzymology; Female; Glomerular Filtration Rate; Glutathione Peroxidase - blood; Humans; Kidney Diseases - blood; Kidney Diseases - classification; Kidney Diseases - complications; Kidney Diseases - physiopathology; Male; Malondialdehyde - blood; Middle Aged; Oxidative Stress; Selenium - blood; Severity of Illness Index; Superoxide Dismutase - blood; Vasodilation - physiology; Zinc - blood

Oxidative stress is related to endothelial dysfunction (ED) and cardiovascular outcomes in patients with chronic kidney disease. Increased asymmetric dimethylarginine (ADMA) levels are among the main causes of ED. We aim to investigate any association between ED and ADMA levels, as well as levels of...