Impact of hypoxia on DNA repair and genome integrity

• Published in: Mutagenesis Vol. 35; no. 1; pp. 61 - 68
• Main Authors: Kaplan, Alanna R, Glazer, Peter M
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 13.02.2020
• Subjects: Cell Hypoxia; DNA Mismatch Repair; DNA Repair; Gene Expression Regulation, Neoplastic; Genome; Genomic Instability; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Recombinational DNA Repair; Reviews; Tumor Hypoxia - drug effects; Tumor Microenvironment - genetics

Abstract Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour biology, influencing cancer progression, the development of metastasis and patient outcome. Hypoxia also contributes to genomic instability and mutation frequency by inhibiting DNA repair pathways. This rev...