Cerebral benzodiazepine receptors in depressed patients measured with [ 123i]iomazenil SPECT

• Published in: Biological psychiatry (1969) Vol. 54; no. 8; pp. 792 - 799
• Main Authors: Kugaya, Akira, Sanacora, Gerard, Verhoeff, Nicolaas P.L.G, Fujita, Masahiro, Mason, Graeme F, Seneca, Nicholas M, Bozkurt, Ali, Khan, Shaukat A, Anand, Amit, Degen, Kathleen, Charney, Dennis S, Zoghbi, Sami S, Baldwin, Ronald M, Seibyl, John P, Innis, Robert B
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.10.2003; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; benzodiazepine receptor; Binding Sites; Biological and medical sciences; Brain - metabolism; Depression; Depressive Disorder, Major - metabolism; Female; Flumazenil - analogs & derivatives; Flumazenil - pharmacokinetics; GABA; gamma-Aminobutyric Acid - metabolism; Humans; Investigative techniques, diagnostic techniques (general aspects); iomazenil; major depression; Male; Medical sciences; Mood disorders; MRS; Nervous system; Occipital Lobe - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radionuclide investigations; Receptors, GABA - metabolism; Receptors, GABA-A - metabolism; SPECT; Tomography, Emission-Computed, Single-Photon; GABA; iomazenil; benzodiazepine receptor; major depression; SPECT; MRS; Radionuclide study; Mood disorder; Human; Depression; Exploration; Benzodiazepine receptor; Single photon emission tomography; Iomazenil(123I); Chemotherapy; Treatment; Medical imagery; Benzodiazepine derivatives

A recent magnetic resonance spectroscopy (MRS) study revealed low γ-aminobutyric acid (GABA) levels in the occipital cortex of depressed patients. No in vivo study has been reported to measure postsynaptic GABA receptors in the patients. Cortical benzodiazepine (BZ) binding to GABA A receptors was m...