Altered Plasma Nerve Growth Factor-Like Immunoreactivity and Nerve Growth Factor-Receptor Expression in Human Old Age

• Published in: Gerontology (Basel) Vol. 49; no. 3; pp. 185 - 190
• Main Authors: Antonelli, A., Bracci-Laudiero, L., Aloe, L.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.05.2003; S. Karger AG
• Subjects: Adult; Aged; Aged, 80 and over; Aging - immunology; Biological and medical sciences; Carrier Proteins - biosynthesis; Cell physiology; Clinical Section; Fundamental and applied biological sciences. Psychology; Humans; Immunity; Lymphocytes - immunology; Male; Membrane Proteins - biosynthesis; Middle Aged; Molecular and cellular biology; Nerve Growth Factor - blood; Nerve Growth Factor - immunology; Receptor, trkA; Receptors, Nerve Growth Factor - biosynthesis; Receptors, Nerve Growth Factor - immunology; Responses to growth factors, tumor promotors, other factors; Aging; trkA; Inflammation; Cytokines; NGF; Lymphocytes; Human; Senescence; Keyworsds Aging; Biological marker; Nerve growth factor; Gene expression; Growth factor receptor; Polypeptide; Lymphocyte; Elderly
• ISSN: 0304-324X; 1423-0003
• DOI: 10.1159/000069170

Background: Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear....