The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment

• Published in: The Journal of experimental medicine Vol. 181; no. 6; pp. 2153 - 2159
• Main Authors: Ying, S, Taborda-Barata, L, Meng, Q, Humbert, M, Kay, A B
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 01.06.1995
• Subjects: Adult; Allergens; Biopsy; Chemokine CCL5; Chemokine CCL7; Chemotactic Factors - biosynthesis; Cytokines; Dermatitis, Atopic - immunology; Dermatitis, Atopic - metabolism; Dermatitis, Atopic - pathology; Eosinophils - immunology; Female; Gene Expression; Humans; Kinetics; Lymphokines - biosynthesis; Macrophages - immunology; Male; Monocyte Chemoattractant Proteins; RNA, Messenger - biosynthesis; Skin - immunology; Skin - metabolism; Skin - pathology; T-Lymphocytes - immunology; Transcription, Genetic

The C-C chemokines RANTES and monocyte chemotactic protein-3 (MCP-3) are potent chemoattractants in vitro for eosinophils and other cell types associated with allergic reactions. We tested the hypothesis that the allergen-induced infiltration of eosinophils, T cells, and macrophages in the skin of a...