Dual Effect of Methylprednsolone Pulses on Apoptosis of Peripheral Leukocytes in Patients with Renal Diseases

• Published in: International journal of immunopathology and pharmacology Vol. 19; no. 3; pp. 647 - 659
• Main Authors: Stratta, P., Canavese, C., Fenoglio, R., Priolo, G., Grillo, A., Aimo, G., Quaglia, M., Pagni, R.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2006
• Subjects: Adult; Apoptosis - drug effects; CD3 Complex - analysis; Circadian Rhythm; Female; Humans; Kidney Diseases - drug therapy; Kidney Diseases - immunology; Kidney Diseases - pathology; Leukocytes - cytology; Leukocytes - drug effects; Male; Methylprednisolone - administration & dosage; Methylprednisolone - pharmacology; Middle Aged; Prospective Studies; T-Lymphocyte Subsets - drug effects; lymphocyte subsets; Systemic Lupus Erythematosus; vasculitis; primary glomerulonephritis; apoptosis; membranous glomerulonephritis; steroid

It is well known that change in apoptosis may modulate the natural story of illness, and that many drugs may act through modulation of apoptosis, but the role of steroids in acting through apoptosis in different settings, including renal diseases, has still to be elucidated. We studied the in vivo e...