The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease

• Published in: Rheumatology (Oxford, England) Vol. 56; no. 4; pp. kew273 - 515
• Main Authors: Dejaco, Christian, Duftner, Christina, Buttgereit, Frank, Matteson, Eric L., Dasgupta, Bhaskar
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Aged; Cytokines - physiology; Dendritic Cells - physiology; Diagnosis, Differential; Fluorodeoxyglucose F18; Giant Cell Arteritis - complications; Giant Cell Arteritis - diagnosis; Giant Cell Arteritis - therapy; Humans; Magnetic Resonance Angiography; Polymyalgia Rheumatica - complications; Polymyalgia Rheumatica - diagnosis; Polymyalgia Rheumatica - therapy; Positron-Emission Tomography; Radiopharmaceuticals; T-Lymphocytes - physiology; giant cell arteritis; biological therapies; vasculitis; immunosuppressants; diagnostic imaging; polymyalgia rheumatica

GCA and PMR are conditions of older persons that frequently overlap. The traditional concept of GCA has focused on cranial symptoms such as headache and visual disturbance, but extra-cranial manifestations such as constitutional symptoms, polymyalgia and limb claudication have also long been recogni...