FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

• Published in: Brain (London, England : 1878) Vol. 141; no. 4; pp. 1201 - 1217
• Main Authors: Botha, Hugo, Mantyh, William G, Murray, Melissa E, Knopman, David S, Przybelski, Scott A, Wiste, Heather J, Graff-Radford, Jonathan, Josephs, Keith A, Schwarz, Christopher G, Kremers, Walter K, Boeve, Bradley F, Petersen, Ronald C, Machulda, Mary M, Parisi, Joseph E, Dickson, Dennis W, Lowe, Val, Jack, Clifford R, Jones, David T
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2018
• Subjects: Aged; Aged, 80 and over; Amyloid beta-Peptides - metabolism; Aniline Compounds - pharmacokinetics; Autopsy; Cohort Studies; Dementia - diagnostic imaging; Dementia - metabolism; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Original; Positron-Emission Tomography; Sclerosis - diagnostic imaging; tau Proteins - metabolism; Thiazoles - pharmacokinetics; FDG-PET; tau-PET; Alzheimer's disease; hippocampal sclerosis; TDP-43
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awy049

See Gordon (doi:10.1093/brain/awy052) for a scientific commentary on this article. There are no antemortem markers of hippocampal sclerosis of ageing. Botha et al. describe a distinct FDG-PET pattern in tau-negative amnestic dementia and show that this corresponds to the pattern seen in autopsy-conf...