Copper-Catalyzed Tandem CN Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines
Cinn‐tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building blocks provides a new, flexible route to an under‐developed class of aromatic heterocycles, cinnolines (see scheme).
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| Published in | Angewandte Chemie International Edition Vol. 51; no. 23; pp. 5718 - 5722 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Weinheim
WILEY-VCH Verlag
04.06.2012
WILEY‐VCH Verlag Wiley |
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| Abstract | Cinn‐tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building blocks provides a new, flexible route to an under‐developed class of aromatic heterocycles, cinnolines (see scheme). |
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| AbstractList | Cinn‐tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building blocks provides a new, flexible route to an under‐developed class of aromatic heterocycles, cinnolines (see scheme). |
| Author | Willis, Michael C. Gilmore, Jeremy Ball, Catherine J. |
| Author_xml | – sequence: 1 givenname: Catherine J. surname: Ball fullname: Ball, Catherine J. organization: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK) http://mcwillis.chem.ox.ac.uk/MCW/Home.html – sequence: 2 givenname: Jeremy surname: Gilmore fullname: Gilmore, Jeremy organization: Lilly Research Centre, Eli Lilly and Company Ltd. Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH (UK) – sequence: 3 givenname: Michael C. surname: Willis fullname: Willis, Michael C. email: michael.willis@chem.ox.ac.uk organization: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK) http://mcwillis.chem.ox.ac.uk/MCW/Home.html |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22539417$$D View this record in MEDLINE/PubMed |
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| Keywords | ROUTE cinnolines NITROGEN-HETEROCYCLES ANTICANCER AGENTS copper catalysis tandem processes AMINATION annulation FACILE SYNTHESIS LIGANDS heterocycles ALKENYL ANTIFUNGAL DERIVATIVES |
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| Snippet | Cinn‐tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building... Cinn-tillating synthesis: The combination of a readily available copper catalyst, a simple hydrazide nucleophile, and established difunctionalized building... |
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| SubjectTerms | annulation Bonding Carbon - chemistry Catalysis Catalysts Chemistry Chemistry, Multidisciplinary cinnolines Copper Copper - chemistry copper catalysis Cyclization heterocycles Heterocyclic Compounds, 2-Ring - chemical synthesis Heterocyclic Compounds, 2-Ring - chemistry Hydrazides Hydrazines - chemistry Nitrogen - chemistry Nucleophiles Physical Sciences Science & Technology Synthesis tandem processes |
| Title | Copper-Catalyzed Tandem CN Bond Formation: An Efficient Annulative Synthesis of Functionalized Cinnolines |
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