BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen

• Published in: Angewandte Chemie International Edition Vol. 60; no. 36; pp. 19912 - 19920
• Main Authors: Teng, Kun‐Xu, Chen, Wen‐Kai, Niu, Li‐Ya, Fang, Wei‐Hai, Cui, Ganglong, Yang, Qing‐Zheng
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.09.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: BODIPY; Charge transfer; Chemistry; Chemistry, Multidisciplinary; Dimers; Energy gap; Hypoxia; Irradiation; Light irradiation; Oxygen; Photodynamic therapy; photosensitizers; Physical Sciences; Radicals; Reactive oxygen species; Science & Technology; Singlet oxygen; Superoxide; superoxide radical; Trimers; Tumors; hypoxia; BODIPY; TUMOR HYPOXIA; photodynamic therapy; superoxide radical; DIMERIZATION; photosensitizers; CANCER; 2ND-ORDER PERTURBATION-THEORY; EXCITED-STATES; MOLECULAR DESIGN; NANOPARTICLES; THERAPY; CHARGE-TRANSFER

Developing Type‐I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge to design photosensitizers for generating reactive oxygen species by the Type‐I process. Herein, we repor...