Expression, glycosylation and function of recombinant anti‐colorectal cancer mAb CO17‐1A in SfSWT4 insect cells

• Published in: Entomological research Vol. 44; no. 1; pp. 39 - 46
• Main Authors: Park, Se‐Ra, Shin, Yong Kyoo, Lee, Kyung Jin, Lee, Jeong‐Hwan, Hedin, David, Mulvania, Thera, Lee, Seung Ho, Ko, Kisung
• Format: Journal Article
• Language: English
• Published: Blackwell Publishing Ltd 2014; 한국곤충학회
• Subjects: antibodies; Antigen (tumor-associated); antigens; Baculovirus; cancer cell; colon cancer; colorectal neoplasms; endoplasmic reticulum; glycan; glycoprotein; glycoproteins; glycosylation; insects; surface plasmon resonance; transgenic insects; 생물학

Colorectal cancer is a commonly diagnosed cancer in the world. Monoclonal antibody (mAb) CO17‐1A recognizes the tumor‐associated antigen GA733, a cell surface glycoprotein highly expressed in colorectal carcinoma cell, which is considered to be applicable for diagnosis and therapeutic treatment agai...