Recent Advances in PROTAC Technology Toward New Therapeutic Modalities

• Published in: Chemistry & biodiversity Vol. 19; no. 11; pp. e202200828 - n/a
• Main Authors: Yokoo, Hidetomo, Naganuma, Miyako, Oba, Makoto, Demizu, Yosuke
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.11.2022
• Subjects: Allosteric properties; Binding; Chimeras; Drug resistance; Ligands; new modality; Nucleic acids; nucleotide; Nucleotides; Oligopeptides; peptide; Peptides; PROTAC; Proteasomes; Proteins; Proteolysis; Selectivity; small molecule; Ubiquitin; Ubiquitin-protein ligase

Proteolysis targeting chimeras (PROTACs) have emerged as a powerful technology for the degradation of disease‐related proteins by the hijacking of the endogenous ubiquitin‐proteasome system. A multitude of bifunctional PROTACs have been developed using small‐molecule ligands; one ligand binds to the...