Selective Inhibition of PAR4 (Protease-Activated Receptor 4)-Mediated Platelet Activation by a Synthetic Nonanticoagulant Heparin Analog - Lin, Yu-Chuan; Ko, Yen-Chun; Hung, Shang-Cheng; Lin, Ying-Ting; Lee, Jia-Hau; Tsai, Ju-Ying; Kung, Po-Hsiung; Tsai, Meng-Chun; Chen, Yih-Fung; Wu, Chin-Chung (Arteriosclerosis, thrombosis, and vascular biology, 2019)
Keywords: Animals; Antithrombins - chemical synthesis; Antithrombins - pharmacology; Calcium Signaling - drug effects; CHO Cells; Computer Simulation; Cricetulus; Drug Evaluation, Preclinical; Heparin - chemistry; Humans; In Vitro Techniques; Models, Molecular; Oligosaccharides - pharmacology; Platelet Aggregation - drug effects; Receptors, Thrombin - antagonists & inhibitors; Recombinant Proteins - drug effects; Thrombin - pharmacology; Thrombosis - prevention & control; heparin; protease-activated receptor 4; thrombin; arrestin; platelet activation; platelet aggregation