Immunocytochemical evaluation of HER-2/neu on fine-needle aspirates from primary breast carcinomas

• Published in: Diagnostic cytopathology Vol. 28; no. 3; pp. 142 - 146
• Main Authors: Nizzoli, Rita, Bozzetti, Cecilia, Crafa, Pellegrino, Naldi, Nadia, Guazzi, Annamaria, Di Blasio, Beatrice, Camisa, Roberta, Cascinu, Stefano
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.03.2003; Wiley-Liss
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Biological and medical sciences; Biopsy, Needle - methods; breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; False Positive Reactions; Female; fine-needle aspiration; FISH; Genital system. Mammary gland; Gynecology. Andrology. Obstetrics; HER-2/neu; Humans; immunocytochemistry; Immunoenzyme Techniques - methods; In Situ Hybridization, Fluorescence; Investigative techniques, diagnostic techniques (general aspects); Mammary gland diseases; Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Receptor, ErbB-2; Reproducibility of Results; RNA, Messenger - metabolism; Tumors; Performance evaluation; Human; Carcinoma; Prognosis; Immunocytochemistry; Malignant tumor; Gene expression; Fine needle aspiration biopsy; Pathology; Mammary gland diseases; Primitive; C-Onc gene; Fluorescence in situ hybridization; Cytopathology; Diagnosis; Mammary gland; Technique; Molecular biology; Comparative study; Protooncogene

Detection of HER‐2/neu alterations is increasingly used in breast cancer patients for therapeutic purposes. This study examines the reliability of HER‐2/neu immunocytochemical assessment on 66 cytospin smears obtained by fine‐needle aspiration biopsy from breast cancer patients. Results were compare...