PKCδ serves as a potential biomarker and therapeutic target for microglia‐mediated neuroinflammation in Alzheimer's disease

• Published in: Alzheimer's & dementia Vol. 20; no. 8; pp. 5511 - 5527
• Main Authors: Du, Ying, Guo, Tiantian, Hao, Yunfeng, Li, Chuan, Tang, Linghui, Li, Xia, Zhang, Xiaoxiao, Li, Lin, Yao, Dan, Xu, Xia, Si, Huaxing, Zhang, Jinghan, Zhao, Nana, Yu, Tong, Zhao, Yingjun, Zhang, Wei, Xu, Huaxi
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.08.2024
• Subjects: Aged; Alzheimer Disease; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Animals; Biomarkers - cerebrospinal fluid; Cytokines - cerebrospinal fluid; Cytokines - metabolism; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; microglia; Microglia - metabolism; neuroinflammation; Neuroinflammatory Diseases - drug therapy; NF-kappa B - metabolism; NF‐κB; PKCδ; Protein Kinase C-delta - metabolism; PKCδ; NF‐κB; neuroinflammation; Alzheimer's disease; microglia

INTRODUCTION To investigate the role of a novel type of protein kinase C delta (PKCδ) in the neuroinflammation of Alzheimer's disease (AD). METHODS We analyzed PKCδ and inflammatory cytokines levels in cerebrospinal fluid (CSF) of AD and normal controls, as well as their correlations. The cellu...