Relationship Between Low Relative Muscle Mass and Coronary Artery Calcification in Healthy Adults
OBJECTIVE—Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of...
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| Published in | Arteriosclerosis, thrombosis, and vascular biology Vol. 36; no. 5; pp. 1016 - 1021 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Heart Association, Inc
01.05.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1079-5642 1524-4636 1524-4636 |
| DOI | 10.1161/ATVBAHA.116.307156 |
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| Abstract | OBJECTIVE—Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults.
APPROACH AND RESULTS—We performed a cross-sectional study of 31 108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31 108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70–3.05), 1.46 (1.15–1.85), and 1.24 (0.98–1.55), respectively (P for trend <0.001). Adjusting for insulin resistance reduced the magnitude of the associations, but they remained statistically significant.
CONCLUSIONS—Relative muscle mass was negatively associated with the prevalence of coronary calcification, supporting low muscle mass as an independent risk factor of coronary heart disease. |
|---|---|
| AbstractList | OBJECTIVE—Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults.
APPROACH AND RESULTS—We performed a cross-sectional study of 31 108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31 108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70–3.05), 1.46 (1.15–1.85), and 1.24 (0.98–1.55), respectively (P for trend <0.001). Adjusting for insulin resistance reduced the magnitude of the associations, but they remained statistically significant.
CONCLUSIONS—Relative muscle mass was negatively associated with the prevalence of coronary calcification, supporting low muscle mass as an independent risk factor of coronary heart disease. Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults. We performed a cross-sectional study of 31 108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31 108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70-3.05), 1.46 (1.15-1.85), and 1.24 (0.98-1.55), respectively (P for trend <0.001). Adjusting for insulin resistance reduced the magnitude of the associations, but they remained statistically significant. Relative muscle mass was negatively associated with the prevalence of coronary calcification, supporting low muscle mass as an independent risk factor of coronary heart disease. Sarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults.OBJECTIVESarcopenia or low muscle mass is related to cardiovascular risk factors; however, the association between low muscle mass and subclinical atherosclerosis has been largely unexplored. We investigated whether muscle mass is related to coronary artery calcification (CAC) in a large sample of middle-aged asymptomatic adults.We performed a cross-sectional study of 31 108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31 108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70-3.05), 1.46 (1.15-1.85), and 1.24 (0.98-1.55), respectively (P for trend <0.001). Adjusting for insulin resistance reduced the magnitude of the associations, but they remained statistically significant.APPROACH AND RESULTSWe performed a cross-sectional study of 31 108 asymptomatic adults without cancer, diabetes mellitus, or known cardiovascular disease who underwent a health checkup examination including cardiac tomography estimation of CAC scores between 2012 and 2013. Skeletal muscle mass index (SMI) [SMI (%)=total skeletal muscle mass (kg)/body weight (kg)×100] was estimated using a bioelectrical impedance analyzer. We assessed the relationship between SMI and CAC scores using both multivariate-adjusted Tobit models and multinomial logistic regression models. Of the 31 108 subjects, 3374 subjects (10.9%) had a CAC score 1 to 100, and 628 subjects (2.0%) had a CAC score >100. SMI was inversely associated with CAC score ratios. Specifically, in a multivariable-adjusted model adjusting for potential confounders, CAC score ratios (95% confidence intervals) of SMI for quartiles 1, 2, and 3 compared with quartile 4 were 2.27 (1.70-3.05), 1.46 (1.15-1.85), and 1.24 (0.98-1.55), respectively (P for trend <0.001). Adjusting for insulin resistance reduced the magnitude of the associations, but they remained statistically significant.Relative muscle mass was negatively associated with the prevalence of coronary calcification, supporting low muscle mass as an independent risk factor of coronary heart disease.CONCLUSIONSRelative muscle mass was negatively associated with the prevalence of coronary calcification, supporting low muscle mass as an independent risk factor of coronary heart disease. |
| Author | Shin, Hocheol Kim, Chan-Won Ko, Byung-Joon Jung, Hyun-Suk Yun, Kyung Eun Chung, Eun Chul Ryu, Seungho Park, Hye Soon Chang, Yoosoo |
| AuthorAffiliation | From the Center for Cohort Studies, Total Healthcare Center (B.-J.K., Y.C., H.-S.J., K.E.Y., C.-W.K., E.C.C., H.S., S.R.), Department of Occupational and Environmental Medicine (Y.C., S.R.), Department of Radiology (E.C.C.), and Department of Family Medicine (H.S.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea (Y.C., S.R.); and Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (H.S.P.) |
| AuthorAffiliation_xml | – name: From the Center for Cohort Studies, Total Healthcare Center (B.-J.K., Y.C., H.-S.J., K.E.Y., C.-W.K., E.C.C., H.S., S.R.), Department of Occupational and Environmental Medicine (Y.C., S.R.), Department of Radiology (E.C.C.), and Department of Family Medicine (H.S.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea (Y.C., S.R.); and Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (H.S.P.) |
| Author_xml | – sequence: 1 givenname: Byung-Joon surname: Ko fullname: Ko, Byung-Joon organization: From the Center for Cohort Studies, Total Healthcare Center (B.-J.K., Y.C., H.-S.J., K.E.Y., C.-W.K., E.C.C., H.S., S.R.), Department of Occupational and Environmental Medicine (Y.C., S.R.), Department of Radiology (E.C.C.), and Department of Family Medicine (H.S.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea (Y.C., S.R.); and Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (H.S.P.) – sequence: 2 givenname: Yoosoo surname: Chang fullname: Chang, Yoosoo – sequence: 3 givenname: Hyun-Suk surname: Jung fullname: Jung, Hyun-Suk – sequence: 4 givenname: Kyung surname: Yun middlename: Eun fullname: Yun, Kyung Eun – sequence: 5 givenname: Chan-Won surname: Kim fullname: Kim, Chan-Won – sequence: 6 givenname: Hye surname: Park middlename: Soon fullname: Park, Hye Soon – sequence: 7 givenname: Eun surname: Chung middlename: Chul fullname: Chung, Eun Chul – sequence: 8 givenname: Hocheol surname: Shin fullname: Shin, Hocheol – sequence: 9 givenname: Seungho surname: Ryu fullname: Ryu, Seungho |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27034471$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adult Asymptomatic Diseases Body Composition Chi-Square Distribution Computed Tomography Angiography Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Cross-Sectional Studies Electric Impedance Female Health Surveys Humans Insulin Resistance Linear Models Logistic Models Male Middle Aged Multidetector Computed Tomography Multivariate Analysis Muscle, Skeletal - physiopathology Predictive Value of Tests Prevalence Risk Factors Sarcopenia - diagnosis Sarcopenia - epidemiology Sarcopenia - physiopathology Seoul - epidemiology Vascular Calcification - diagnostic imaging Vascular Calcification - epidemiology |
| Title | Relationship Between Low Relative Muscle Mass and Coronary Artery Calcification in Healthy Adults |
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