Co‐prescription of low‐dose methotrexate and trimethoprim‐sulfamethoxazole and the 30‐day risk of death among older adults: A cohort study

• Published in: British journal of clinical pharmacology Vol. 91; no. 4; pp. 1263 - 1271
• Main Authors: Sadeghi, Hasti, Ahmadi, Fatemeh, McArthur, Eric, Sontrop, Jessica M., Abdullah, Sheikh S., Urquhart, Brad L., Kim, Richard B., Muanda, Flory T.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.04.2025
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; antifolate; cephalosporins; Cephalosporins - administration & dosage; Cephalosporins - adverse effects; Cohort Studies; dosage; Drug Therapy, Combination; drug–drug interaction; Female; Hospitalization - statistics & numerical data; Humans; low‐dose methotrexate; Male; Methotrexate - administration & dosage; Methotrexate - adverse effects; Ontario - epidemiology; Original; Propensity Score; Retrospective Studies; toxicity; Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage; Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects; trimethoprim‐sulfamethoxazole; Ontario; toxicity; dosage; drug–drug interaction; trimethoprim‐sulfamethoxazole; low‐dose methotrexate; cephalosporins; antifolate

Aims The aim of this study was to characterize the risk of death in older adults co‐prescribed low‐dose methotrexate and TMP‐SMX vs. low‐dose methotrexate and a cephalosporin. Methods We conducted a retrospective, population‐based, new‐user cohort study in Ontario, Canada (April 1, 2002–August 1, 20...