Calycosin inhibits the proliferation and metastasis of renal cell carcinoma through the MAZ/HAS2 signaling pathway - Zhang, Zi‐Hao; Yuan, Cheng‐Yue; Xu, Meng; Wang, Meng‐Fei; Feng, Tao; Wang, Yue; Zheng, Sheng‐Feng; Zhang, Hai‐Liang; Shi, Guo‐Hai; Cao, Da‐Long; Wang, Zi‐Liang; Ye, Ding‐Wei (Phytotherapy research, 2024)
Keywords: Animal models; Animals; Apoptosis; Apoptosis - drug effects; Calycosin; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; Cell adhesion; Cell culture; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Degradation; DNA-Binding Proteins - metabolism; Flavonoids; Gene Expression Regulation, Neoplastic - drug effects; Gene sequencing; HAS2; Humans; Hyaluronic acid; Immunoprecipitation; Isoflavones - pharmacology; Kidney cancer; Kidney Neoplasms - drug therapy; Kidney Neoplasms - pathology; luciferase; MAZ; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Pharmacology; phytotherapy; precipitin tests; Proteasomes; Renal cell carcinoma; reverse transcriptase polymerase chain reaction; Reverse transcription; sequence analysis; Signal transduction; Signal Transduction - drug effects; Target detection; transcription factors; Transcription Factors - metabolism; Ubiquitin; Ubiquitination; ubiquitin‐proteasome pathway; Western blotting; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation; HAS2; renal cell carcinoma; Calycosin; ubiquitin‐proteasome pathway; MAZ