Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

• Published in: Advanced materials (Weinheim) Vol. 32; no. 40; pp. e2002054 - n/a
• Main Authors: Xia, Yuqiong, Rao, Lang, Yao, Huimin, Wang, Zhongliang, Ning, Pengbo, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.10.2020
• Subjects: Cancer; cancer immunotherapy; Depletion; Drug carriers; drug delivery; Drug delivery systems; Immunotherapy; macrophage membrane coatings; Macrophages; macrophage‐derived exosomes; Nanoparticles; Tumors; tumor‐associated macrophages

Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 macrophages such as tumor‐associated macrophages (TAMs) promote tumor growth and invasion. Modulating the tumor immune microenvironment thro...