mRNA Delivery by a pH‐Responsive DNA Nano‐Hydrogel

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 29; pp. e2101224 - n/a
• Main Authors: Fu, Xin, Chen, Tianshu, Song, Yuchen, Feng, Chang, Chen, Huinan, Zhang, Qianqian, Chen, Guifang, Zhu, Xiaoli
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.07.2021
• Subjects: Biocompatibility; Crosslinking; delivery; Efficiency; Gaussia luciferase; Gene expression; green fluorescent proteins; Hydrogels; mRNA; Mutation; Nanospheres; Nanotechnology; nano‐hydrogels; Proteins

The delivery of mRNA to manipulate protein expression has attracted widespread attention, since that mRNA overcomes the problem of infection and mutation risks in transgenes and can work as drugs for the treatment of diseases. Although there are currently some vehicles that deliver mRNA into cells,...