Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers

• Published in: Alzheimer's & dementia Vol. 21; no. 6; pp. e70353 - n/a
• Main Authors: Stankeviciute, Laura, Tort‐Colet, Núria, Fernández‐Arcos, Ana, Sánchez‐Benavides, Gonzalo, Minguillón, Carolina, Fauria, Karine, Holst, Sebastian Camillo, Garcés, Pilar, Mueggler, Thomas, Zetterberg, Henrik, Blennow, Kaj, Iranzo, Álex, Suárez‐Calvet, Marc, Gispert, Juan Domingo, Molinuevo, José Luis, Grau‐Rivera, Oriol
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.06.2025
• Subjects: Actigraphy; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Brain - diagnostic imaging; Brain - pathology; cortical thickness; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurosciences; Neurovetenskaper; Peptide Fragments - cerebrospinal fluid; preclinical AD; sex differences; Sex Factors; sleep; Sleep - physiology; Sleep Wake Disorders; tau Proteins - cerebrospinal fluid; preclinical AD; sleep; actigraphy; cortical thickness; sex differences

INTRODUCTION Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and...