BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures
Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabol...
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| Published in | Neuron (Cambridge, Mass.) Vol. 74; no. 4; pp. 719 - 730 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Elsevier Inc
24.05.2012
Elsevier Limited |
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| Online Access | Get full text |
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| Abstract | Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phosphoregulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive KATP channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the KATP channel, implicating the BAD-KATP axis in metabolic control of neuronal excitation and seizure responses.
► Genetic alteration of BAD blunts epileptic seizures without affecting cognition ► BAD modulates seizure sensitivity through metabolic and not apoptotic signaling ► BAD has reciprocal effects on oxidation of glucose and ketone bodies by brain cells ► KATP channels mediate the anticonvulsant effect of BAD alteration
Gimenez-Cassina et al. show that alteration of fuel metabolism by genetic modification of BAD can blunt epileptic seizures in mice. These genetic modifications also enhance the activity of metabolically sensitive KATP channels, which in turn are required for BAD's anticonvulsant effect. |
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| AbstractList | Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phosphoregulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive KATP channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the KATP channel, implicating the BAD-KATP axis in metabolic control of neuronal excitation and seizure responses. Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phosphoregulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive KATPchannels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the KATPchannel, implicating the BAD-KATPaxis in metabolic control of neuronal excitation and seizure responses. Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phospho-regulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive K ATP channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo . Seizure resistance is reversed by genetic ablation of the K ATP channel, implicating the BAD-K ATP axis in metabolic control of neuronal excitation and seizure responses. Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phosphoregulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive KATP channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the KATP channel, implicating the BAD-KATP axis in metabolic control of neuronal excitation and seizure responses. ► Genetic alteration of BAD blunts epileptic seizures without affecting cognition ► BAD modulates seizure sensitivity through metabolic and not apoptotic signaling ► BAD has reciprocal effects on oxidation of glucose and ketone bodies by brain cells ► KATP channels mediate the anticonvulsant effect of BAD alteration Gimenez-Cassina et al. show that alteration of fuel metabolism by genetic modification of BAD can blunt epileptic seizures in mice. These genetic modifications also enhance the activity of metabolically sensitive KATP channels, which in turn are required for BAD's anticonvulsant effect. |
| Author | Martínez-François, Juan Ramón Lutas, Andrew Polak, Klaudia Danial, Nika N. Tanner, Geoffrey R. Wiwczar, Jessica Szlyk, Benjamin Giménez-Cassina, Alfredo Fisher, Jill K. Yellen, Gary |
| AuthorAffiliation | 3 Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA 1 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston MA 02215, USA 2 Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA |
| AuthorAffiliation_xml | – name: 2 Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA – name: 3 Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA – name: 1 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston MA 02215, USA |
| Author_xml | – sequence: 1 givenname: Alfredo surname: Giménez-Cassina fullname: Giménez-Cassina, Alfredo organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA – sequence: 2 givenname: Juan Ramón surname: Martínez-François fullname: Martínez-François, Juan Ramón organization: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA – sequence: 3 givenname: Jill K. surname: Fisher fullname: Fisher, Jill K. organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA – sequence: 4 givenname: Benjamin surname: Szlyk fullname: Szlyk, Benjamin organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA – sequence: 5 givenname: Klaudia surname: Polak fullname: Polak, Klaudia organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA – sequence: 6 givenname: Jessica surname: Wiwczar fullname: Wiwczar, Jessica organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA – sequence: 7 givenname: Geoffrey R. surname: Tanner fullname: Tanner, Geoffrey R. organization: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA – sequence: 8 givenname: Andrew surname: Lutas fullname: Lutas, Andrew organization: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA – sequence: 9 givenname: Gary surname: Yellen fullname: Yellen, Gary email: gary_yellen@hms.harvard.edu organization: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA – sequence: 10 givenname: Nika N. surname: Danial fullname: Danial, Nika N. email: nika_danial@dfci.harvard.edu organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA |
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| Cites_doi | 10.1016/S0896-6273(00)80124-5 10.1016/j.eplepsyres.2005.03.008 10.1212/01.wnl.0000187071.24292.9e 10.1016/j.pediatrneurol.2007.02.008 10.1046/j.1528-1157.44.s7.4.x 10.1038/onc.2009.44 10.1016/S1097-2765(05)00012-2 10.1016/S0014-5793(96)01438-X 10.1002/jnr.10553 10.1016/j.pbiomolbio.2008.10.002 10.1016/S0092-8674(04)00046-7 10.1111/j.1471-4159.2009.05941.x 10.1111/j.1528-1167.2008.01843.x 10.1152/ajpcell.00247.2006 10.1016/j.expneurol.2011.09.001 10.1016/j.neuron.2011.04.004 10.1016/S0920-1211(02)00262-0 10.1016/0920-1211(90)90002-D 10.1016/j.neuron.2010.09.002 10.1016/j.bbabio.2009.03.010 10.1016/j.neuroscience.2010.03.057 10.1038/nn1573 10.1111/j.1528-1167.2008.01832.x 10.1038/jcbfm.2011.26 10.1111/j.1528-1167.2008.01870.x 10.1038/nature01825 10.1152/ajpendo.00093.2009 10.1038/nn.2132 10.1016/S0006-8993(98)00956-1 10.1016/0006-8993(80)90316-9 10.1172/JCI57813 10.1073/pnas.0504783102 10.1038/cdd.2009.134 10.1038/nrm2308 10.1016/S0079-6123(07)63032-5 10.1523/JNEUROSCI.5951-10.2011 10.1038/nm1717 10.1111/j.1528-1157.2000.tb04600.x 10.1038/nature04711 10.1007/s003359900389 10.1172/JCI105650 10.1002/jnr.10083 10.1002/ana.410030410 10.1111/j.1460-9568.2010.07345.x 10.1016/S0920-1211(99)00069-8 10.1073/pnas.95.18.10402 10.1038/23730 10.1002/mrm.10429 10.1038/nn1791 10.1111/j.1528-1157.1999.tb00875.x 10.1016/j.molcel.2010.01.025 10.1042/BJ20110162 10.1523/JNEUROSCI.19-16-06733.1999 10.1152/jn.00598.2007 10.1016/S0014-2999(98)00410-5 10.1523/JNEUROSCI.0132-07.2007 10.1111/j.1528-1157.1999.tb02066.x 10.1002/ana.21603 10.1152/jn.91062.2008 10.1111/j.1471-4159.2008.05460.x |
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| References | Danial, Gramm, Scorrano, Zhang, Krauss, Ranger, Datta, Greenberg, Licklider, Lowell (bib13) 2003; 424 Neal, Chaffe, Schwartz, Lawson, Edwards, Fitzsimmons, Whitney, Cross (bib43) 2009; 50 Heinemann, Beck, Dreier, Ficker, Stabel, Zhang (bib26) 1992; 7 Wang, Bergqvist, Hunter, Jin, Wang, Wehrli, Zimmerman (bib58) 2003; 49 Wu, Neilson, Swift, Moran, Tamagnine, Parslow, Armistead, Lemire, Orrell, Teich (bib59) 2007; 292 Brenner, Chen, Vilaythong, Toney, Noebels, Aldrich (bib5) 2005; 8 Datta, Katsov, Hu, Petros, Fesik, Yaffe, Greenberg (bib15) 2000; 6 Danial, Walensky, Zhang, Choi, Fisher, Molina, Datta, Pitter, Bird, Wikstrom (bib14) 2008; 14 Coulter (bib8) 1999; 40 Noh, Kim, Lee, Chung, Kim, Kang, Cho, Choi (bib46) 2003; 53 Browning, Wang, Lanker, Jobe (bib7) 1990; 6 Pfeifer, Thiele (bib48) 2005; 65 Jarrett, Milder, Liang, Patel (bib31) 2008; 106 Bough, Eagles (bib3) 1999; 40 Yellen (bib60) 2008; 49 Karschin, Ecke, Ashcroft, Karschin (bib35) 1997; 401 Engel, Hatazaki, Tanaka, Prehn, Henshall (bib18) 2010; 168 Zielke, Zielke, Baab (bib65) 2009; 109 Ferraro, Golden, Smith, St Jean, Schork, Mulholland, Ballas, Schill, Buono, Berrettini (bib22) 1999; 19 Ferraro, Golden, Smith, Schork, St Jean, Ballas, Choi, Berrettini (bib21) 1997; 8 Murphy, Engel, Paucard, Hatazaki, Mouri, Tanaka, Tuffy, Jimenez-Mateos, Woods, Dunleavy (bib42) 2010; 17 Tanner, Lutas, Martínez-François, Yellen (bib55) 2011; 31 Brand, Nicholls (bib4) 2011; 435 Zawar, Plant, Schirra, Konnerth, Neumcke (bib64) 1999; 514 Velíšková (bib57) 2005 Haugvicová, Kubová, Skutová, Mares (bib25) 2000; 41 Schwartzkroin (bib51) 1999; 37 Pfeifer, Lyczkowski, Thiele (bib49) 2008; 49 Ma, Berg, Yellen (bib38) 2007; 27 Hue, Taegtmeyer (bib29) 2009; 297 Inagaki, Gonoi, Clement, Wang, Aguilar-Bryan, Bryan, Seino (bib30) 1996; 16 Miki, Nagashima, Tashiro, Kotake, Yoshitomi, Tamamoto, Gonoi, Iwanaga, Miyazaki, Seino (bib41) 1998; 95 Hsu (bib28) 2007; 163 Thiele (bib56) 2003; 44 Masino, Li, Theofilas, Sandau, Ruskin, Fredholm, Geiger, Aronica, Boison (bib40) 2011; 121 Jiao, Li (bib33) 2011; 70 Nichols (bib44) 2006; 440 Garriga-Canut, Schoenike, Qazi, Bergendahl, Daley, Pfender, Morrison, Ockuly, Stafstrom, Sutula, Roopra (bib23) 2006; 9 Hickman, Hardwick, Kaczmarek, Jonas (bib27) 2008; 99 Danial, Korsmeyer (bib12) 2004; 116 Stafstrom, Ockuly, Murphree, Valley, Roopra, Sutula (bib53) 2009; 65 Fern (bib20) 2003; 71 Dahlin, Elfving, Ungerstedt, Amark (bib10) 2005; 64 Hartman, Gasior, Vining, Rogawski (bib24) 2007; 36 Ziemann, Schnizler, Albert, Severson, Howard, Welsh, Wemmie (bib66) 2008; 11 Ben-Ari, Tremblay, Ottersen, Meldrum (bib2) 1980; 191 Lehmkuhle, Thomson, Scheerlinck, Pouliot, Greger, Dudek (bib37) 2009; 101 Yin, Wang, Gross, Zhao, Zinkel, Klocke, Roth, Korsmeyer (bib61) 1999; 400 Chipuk, Moldoveanu, Llambi, Parsons, Green (bib9) 2010; 37 Yudkoff, Daikhin, Nissim, Lazarow, Nissim (bib63) 2001; 66 Banker, Goslin (bib1) 1998 Danial (bib11) 2008; 27 Engel, Plesnila, Prehn, Henshall (bib19) 2011; 31 DeVivo, Leckie, Ferrendelli, McDougal (bib16) 1978; 3 Klitgaard, Matagne, Gobert, Wülfert (bib36) 1998; 353 Jeong, Jeon, Shin, Kim, Lee, Kim, Kang, Cho, Choi, Roh (bib32) 2011; 232 MacAskill, Atkin, Kittler (bib39) 2010; 32 Juge, Gray, Omote, Miyaji, Inoue, Hara, Uneyama, Edwards, Nicoll, Moriyama (bib34) 2010; 68 Stafstrom, Rho (bib52) 2004 Dunn-Meynell, Rawson, Levin (bib17) 1998; 814 Youle, Strasser (bib62) 2008; 9 Proks, Ashcroft (bib50) 2009; 99 Owen, Morgan, Kemp, Sullivan, Herrera, Cahill (bib47) 1967; 46 Takeuchi, Fisher, Suh, Harada, Malynn, Korsmeyer (bib54) 2005; 102 Browning (bib6) 1994 Nicholls (bib45) 2009; 1787 Danial (10.1016/j.neuron.2012.03.032_bib13) 2003; 424 Neal (10.1016/j.neuron.2012.03.032_bib43) 2009; 50 Takeuchi (10.1016/j.neuron.2012.03.032_bib54) 2005; 102 Hsu (10.1016/j.neuron.2012.03.032_bib28) 2007; 163 Klitgaard (10.1016/j.neuron.2012.03.032_bib36) 1998; 353 Karschin (10.1016/j.neuron.2012.03.032_bib35) 1997; 401 Yin (10.1016/j.neuron.2012.03.032_bib61) 1999; 400 Browning (10.1016/j.neuron.2012.03.032_bib6) 1994 Hickman (10.1016/j.neuron.2012.03.032_bib27) 2008; 99 Noh (10.1016/j.neuron.2012.03.032_bib46) 2003; 53 Velíšková (10.1016/j.neuron.2012.03.032_bib57) 2005 Nichols (10.1016/j.neuron.2012.03.032_bib44) 2006; 440 Ben-Ari (10.1016/j.neuron.2012.03.032_bib2) 1980; 191 Stafstrom (10.1016/j.neuron.2012.03.032_bib53) 2009; 65 Banker (10.1016/j.neuron.2012.03.032_bib1) 1998 Masino (10.1016/j.neuron.2012.03.032_bib40) 2011; 121 Juge (10.1016/j.neuron.2012.03.032_bib34) 2010; 68 Brenner (10.1016/j.neuron.2012.03.032_bib5) 2005; 8 Wang (10.1016/j.neuron.2012.03.032_bib58) 2003; 49 Danial (10.1016/j.neuron.2012.03.032_bib12) 2004; 116 Stafstrom (10.1016/j.neuron.2012.03.032_bib52) 2004 Yellen (10.1016/j.neuron.2012.03.032_bib60) 2008; 49 DeVivo (10.1016/j.neuron.2012.03.032_bib16) 1978; 3 Danial (10.1016/j.neuron.2012.03.032_bib14) 2008; 14 Zawar (10.1016/j.neuron.2012.03.032_bib64) 1999; 514 Youle (10.1016/j.neuron.2012.03.032_bib62) 2008; 9 Yudkoff (10.1016/j.neuron.2012.03.032_bib63) 2001; 66 Dahlin (10.1016/j.neuron.2012.03.032_bib10) 2005; 64 Heinemann (10.1016/j.neuron.2012.03.032_bib26) 1992; 7 Fern (10.1016/j.neuron.2012.03.032_bib20) 2003; 71 Proks (10.1016/j.neuron.2012.03.032_bib50) 2009; 99 Bough (10.1016/j.neuron.2012.03.032_bib3) 1999; 40 Browning (10.1016/j.neuron.2012.03.032_bib7) 1990; 6 Pfeifer (10.1016/j.neuron.2012.03.032_bib48) 2005; 65 Dunn-Meynell (10.1016/j.neuron.2012.03.032_bib17) 1998; 814 Pfeifer (10.1016/j.neuron.2012.03.032_bib49) 2008; 49 Jiao (10.1016/j.neuron.2012.03.032_bib33) 2011; 70 Ferraro (10.1016/j.neuron.2012.03.032_bib21) 1997; 8 Chipuk (10.1016/j.neuron.2012.03.032_bib9) 2010; 37 Wu (10.1016/j.neuron.2012.03.032_bib59) 2007; 292 Engel (10.1016/j.neuron.2012.03.032_bib18) 2010; 168 Jeong (10.1016/j.neuron.2012.03.032_bib32) 2011; 232 Engel (10.1016/j.neuron.2012.03.032_bib19) 2011; 31 Coulter (10.1016/j.neuron.2012.03.032_bib8) 1999; 40 Hue (10.1016/j.neuron.2012.03.032_bib29) 2009; 297 Schwartzkroin (10.1016/j.neuron.2012.03.032_bib51) 1999; 37 Lehmkuhle (10.1016/j.neuron.2012.03.032_bib37) 2009; 101 Haugvicová (10.1016/j.neuron.2012.03.032_bib25) 2000; 41 Nicholls (10.1016/j.neuron.2012.03.032_bib45) 2009; 1787 Zielke (10.1016/j.neuron.2012.03.032_bib65) 2009; 109 Garriga-Canut (10.1016/j.neuron.2012.03.032_bib23) 2006; 9 Owen (10.1016/j.neuron.2012.03.032_bib47) 1967; 46 Danial (10.1016/j.neuron.2012.03.032_bib11) 2008; 27 Datta (10.1016/j.neuron.2012.03.032_bib15) 2000; 6 Ma (10.1016/j.neuron.2012.03.032_bib38) 2007; 27 Brand (10.1016/j.neuron.2012.03.032_bib4) 2011; 435 Ziemann (10.1016/j.neuron.2012.03.032_bib66) 2008; 11 Ferraro (10.1016/j.neuron.2012.03.032_bib22) 1999; 19 Hartman (10.1016/j.neuron.2012.03.032_bib24) 2007; 36 Murphy (10.1016/j.neuron.2012.03.032_bib42) 2010; 17 Tanner (10.1016/j.neuron.2012.03.032_bib55) 2011; 31 Inagaki (10.1016/j.neuron.2012.03.032_bib30) 1996; 16 Jarrett (10.1016/j.neuron.2012.03.032_bib31) 2008; 106 Thiele (10.1016/j.neuron.2012.03.032_bib56) 2003; 44 MacAskill (10.1016/j.neuron.2012.03.032_bib39) 2010; 32 Miki (10.1016/j.neuron.2012.03.032_bib41) 1998; 95 |
| References_xml | – volume: 70 start-page: 758 year: 2011 end-page: 772 ident: bib33 article-title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission publication-title: Neuron contributor: fullname: Li – volume: 37 start-page: 171 year: 1999 end-page: 180 ident: bib51 article-title: Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet publication-title: Epilepsy Res. contributor: fullname: Schwartzkroin – volume: 8 start-page: 1752 year: 2005 end-page: 1759 ident: bib5 article-title: BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures publication-title: Nat. Neurosci. contributor: fullname: Aldrich – volume: 1787 start-page: 1416 year: 2009 end-page: 1424 ident: bib45 article-title: Mitochondrial calcium function and dysfunction in the central nervous system publication-title: Biochim. Biophys. Acta contributor: fullname: Nicholls – volume: 40 start-page: 138 year: 1999 end-page: 143 ident: bib3 article-title: A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat publication-title: Epilepsia contributor: fullname: Eagles – volume: 53 start-page: 119 year: 2003 end-page: 128 ident: bib46 article-title: The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice publication-title: Epilepsy Res. contributor: fullname: Choi – volume: 102 start-page: 11272 year: 2005 end-page: 11277 ident: bib54 article-title: Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Korsmeyer – volume: 6 start-page: 1 year: 1990 end-page: 11 ident: bib7 article-title: Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern publication-title: Epilepsy Res. contributor: fullname: Jobe – volume: 6 start-page: 41 year: 2000 end-page: 51 ident: bib15 article-title: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation publication-title: Mol. Cell contributor: fullname: Greenberg – volume: 31 start-page: 8689 year: 2011 end-page: 8696 ident: bib55 article-title: Single K publication-title: J. Neurosci. contributor: fullname: Yellen – volume: 400 start-page: 886 year: 1999 end-page: 891 ident: bib61 article-title: Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis publication-title: Nature contributor: fullname: Korsmeyer – volume: 232 start-page: 195 year: 2011 end-page: 202 ident: bib32 article-title: Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures publication-title: Exp. Neurol. contributor: fullname: Roh – volume: 66 start-page: 931 year: 2001 end-page: 940 ident: bib63 article-title: Ketogenic diet, amino acid metabolism, and seizure control publication-title: J. Neurosci. Res. contributor: fullname: Nissim – volume: 64 start-page: 115 year: 2005 end-page: 125 ident: bib10 article-title: The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy publication-title: Epilepsy Res. contributor: fullname: Amark – start-page: 399 year: 1994 end-page: 414 ident: bib6 article-title: Anatomy of Generalized Convulsive Seizures publication-title: Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects contributor: fullname: Browning – volume: 31 start-page: 1196 year: 2011 end-page: 1210 ident: bib19 article-title: In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Henshall – volume: 36 start-page: 281 year: 2007 end-page: 292 ident: bib24 article-title: The neuropharmacology of the ketogenic diet publication-title: Pediatr. Neurol. contributor: fullname: Rogawski – volume: 32 start-page: 231 year: 2010 end-page: 240 ident: bib39 article-title: Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses publication-title: Eur. J. Neurosci. contributor: fullname: Kittler – year: 1998 ident: bib1 article-title: Culturing Nerve Cells contributor: fullname: Goslin – volume: 16 start-page: 1011 year: 1996 end-page: 1017 ident: bib30 article-title: A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K publication-title: Neuron contributor: fullname: Seino – volume: 292 start-page: C125 year: 2007 end-page: C136 ident: bib59 article-title: Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells publication-title: Am. J. Physiol. Cell Physiol. contributor: fullname: Teich – volume: 49 start-page: 42 year: 2008 end-page: 45 ident: bib49 article-title: Low glycemic index treatment: implementation and new insights into efficacy publication-title: Epilepsia contributor: fullname: Thiele – volume: 163 start-page: 601 year: 2007 end-page: 613 ident: bib28 article-title: The dentate gyrus as a filter or gate: a look back and a look ahead publication-title: Prog. Brain Res. contributor: fullname: Hsu – year: 2004 ident: bib52 article-title: Epilepsy and the Ketogenic Diet contributor: fullname: Rho – volume: 109 start-page: 24 year: 2009 end-page: 29 ident: bib65 article-title: Direct measurement of oxidative metabolism in the living brain by microdialysis: a review publication-title: J. Neurochem. contributor: fullname: Baab – volume: 49 start-page: 615 year: 2003 end-page: 619 ident: bib58 article-title: In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy—exploration of GABA levels in a ketogenic diet publication-title: Magn. Reson. Med. contributor: fullname: Zimmerman – volume: 95 start-page: 10402 year: 1998 end-page: 10406 ident: bib41 article-title: Defective insulin secretion and enhanced insulin action in K publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Seino – volume: 44 start-page: 26 year: 2003 end-page: 29 ident: bib56 article-title: Assessing the efficacy of antiepileptic treatments: the ketogenic diet publication-title: Epilepsia contributor: fullname: Thiele – volume: 9 start-page: 47 year: 2008 end-page: 59 ident: bib62 article-title: The BCL-2 protein family: opposing activities that mediate cell death publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Strasser – volume: 3 start-page: 331 year: 1978 end-page: 337 ident: bib16 article-title: Chronic ketosis and cerebral metabolism publication-title: Ann. Neurol. contributor: fullname: McDougal – volume: 7 start-page: 273 year: 1992 end-page: 280 ident: bib26 article-title: The dentate gyrus as a regulated gate for the propagation of epileptiform activity publication-title: Epilepsy Res. Suppl. contributor: fullname: Zhang – volume: 41 start-page: 1235 year: 2000 end-page: 1240 ident: bib25 article-title: Anticonvulsant action of topiramate against motor seizures in developing rats publication-title: Epilepsia contributor: fullname: Mares – volume: 101 start-page: 1660 year: 2009 end-page: 1670 ident: bib37 article-title: A simple quantitative method for analyzing electrographic status epilepticus in rats publication-title: J. Neurophysiol. contributor: fullname: Dudek – volume: 814 start-page: 41 year: 1998 end-page: 54 ident: bib17 article-title: Distribution and phenotype of neurons containing the ATP-sensitive K publication-title: Brain Res. contributor: fullname: Levin – volume: 99 start-page: 1515 year: 2008 end-page: 1522 ident: bib27 article-title: Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission publication-title: J. Neurophysiol. contributor: fullname: Jonas – volume: 40 start-page: S23 year: 1999 end-page: S33 ident: bib8 article-title: Chronic epileptogenic cellular alterations in the limbic system after status epilepticus publication-title: Epilepsia contributor: fullname: Coulter – volume: 9 start-page: 1382 year: 2006 end-page: 1387 ident: bib23 article-title: 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure publication-title: Nat. Neurosci. contributor: fullname: Roopra – volume: 65 start-page: 435 year: 2009 end-page: 447 ident: bib53 article-title: Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models publication-title: Ann. Neurol. contributor: fullname: Sutula – volume: 353 start-page: 191 year: 1998 end-page: 206 ident: bib36 article-title: Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy publication-title: Eur. J. Pharmacol. contributor: fullname: Wülfert – volume: 297 start-page: E578 year: 2009 end-page: E591 ident: bib29 article-title: The Randle cycle revisited: a new head for an old hat publication-title: Am. J. Physiol. Endocrinol. Metab. contributor: fullname: Taegtmeyer – volume: 401 start-page: 59 year: 1997 end-page: 64 ident: bib35 article-title: Overlapping distribution of K publication-title: FEBS Lett. contributor: fullname: Karschin – volume: 37 start-page: 299 year: 2010 end-page: 310 ident: bib9 article-title: The BCL-2 family reunion publication-title: Mol. Cell contributor: fullname: Green – volume: 168 start-page: 443 year: 2010 end-page: 450 ident: bib18 article-title: Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus publication-title: Neuroscience contributor: fullname: Henshall – volume: 19 start-page: 6733 year: 1999 end-page: 6739 ident: bib22 article-title: Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice publication-title: J. Neurosci. contributor: fullname: Berrettini – volume: 8 start-page: 200 year: 1997 end-page: 208 ident: bib21 article-title: Mapping murine loci for seizure response to kainic acid publication-title: Mamm. Genome contributor: fullname: Berrettini – volume: 435 start-page: 297 year: 2011 end-page: 312 ident: bib4 article-title: Assessing mitochondrial dysfunction in cells publication-title: Biochem. J. contributor: fullname: Nicholls – volume: 14 start-page: 144 year: 2008 end-page: 153 ident: bib14 article-title: Dual role of proapoptotic BAD in insulin secretion and beta cell survival publication-title: Nat. Med. contributor: fullname: Wikstrom – volume: 121 start-page: 2679 year: 2011 end-page: 2683 ident: bib40 article-title: A ketogenic diet suppresses seizures in mice through adenosine A publication-title: J. Clin. Invest. contributor: fullname: Boison – volume: 424 start-page: 952 year: 2003 end-page: 956 ident: bib13 article-title: BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis publication-title: Nature contributor: fullname: Lowell – volume: 49 start-page: 80 year: 2008 end-page: 82 ident: bib60 article-title: Ketone bodies, glycolysis, and K publication-title: Epilepsia contributor: fullname: Yellen – volume: 514 start-page: 327 year: 1999 end-page: 341 ident: bib64 article-title: Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus publication-title: J. Physiol. contributor: fullname: Neumcke – volume: 27 start-page: 3618 year: 2007 end-page: 3625 ident: bib38 article-title: Ketogenic diet metabolites reduce firing in central neurons by opening K publication-title: J. Neurosci. contributor: fullname: Yellen – volume: 116 start-page: 205 year: 2004 end-page: 219 ident: bib12 article-title: Cell death: critical control points publication-title: Cell contributor: fullname: Korsmeyer – volume: 50 start-page: 1109 year: 2009 end-page: 1117 ident: bib43 article-title: A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy publication-title: Epilepsia contributor: fullname: Cross – volume: 65 start-page: 1810 year: 2005 end-page: 1812 ident: bib48 article-title: Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy publication-title: Neurology contributor: fullname: Thiele – start-page: 601 year: 2005 end-page: 611 ident: bib57 article-title: Behavioral Characterization of Seizures in Rats publication-title: Models of Seizures and Epilepsy contributor: fullname: Velíšková – volume: 17 start-page: 459 year: 2010 end-page: 468 ident: bib42 article-title: Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus publication-title: Cell Death Differ. contributor: fullname: Dunleavy – volume: 46 start-page: 1589 year: 1967 end-page: 1595 ident: bib47 article-title: Brain metabolism during fasting publication-title: J. Clin. Invest. contributor: fullname: Cahill – volume: 27 start-page: S53 year: 2008 end-page: S70 ident: bib11 article-title: BAD: undertaker by night, candyman by day publication-title: Oncogene contributor: fullname: Danial – volume: 191 start-page: 79 year: 1980 end-page: 97 ident: bib2 article-title: The role of epileptic activity in hippocampal and “remote” cerebral lesions induced by kainic acid publication-title: Brain Res. contributor: fullname: Meldrum – volume: 11 start-page: 816 year: 2008 end-page: 822 ident: bib66 article-title: Seizure termination by acidosis depends on ASIC1a publication-title: Nat. Neurosci. contributor: fullname: Wemmie – volume: 71 start-page: 759 year: 2003 end-page: 762 ident: bib20 article-title: Variations in spare electron transport chain capacity: The answer to an old riddle? publication-title: J. Neurosci. Res. contributor: fullname: Fern – volume: 106 start-page: 1044 year: 2008 end-page: 1051 ident: bib31 article-title: The ketogenic diet increases mitochondrial glutathione levels publication-title: J. Neurochem. contributor: fullname: Patel – volume: 99 start-page: 7 year: 2009 end-page: 19 ident: bib50 article-title: Modeling K publication-title: Prog. Biophys. Mol. Biol. contributor: fullname: Ashcroft – volume: 68 start-page: 99 year: 2010 end-page: 112 ident: bib34 article-title: Metabolic control of vesicular glutamate transport and release publication-title: Neuron contributor: fullname: Moriyama – volume: 440 start-page: 470 year: 2006 end-page: 476 ident: bib44 article-title: K publication-title: Nature contributor: fullname: Nichols – volume: 16 start-page: 1011 year: 1996 ident: 10.1016/j.neuron.2012.03.032_bib30 article-title: A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels publication-title: Neuron doi: 10.1016/S0896-6273(00)80124-5 contributor: fullname: Inagaki – volume: 64 start-page: 115 year: 2005 ident: 10.1016/j.neuron.2012.03.032_bib10 article-title: The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy publication-title: Epilepsy Res. doi: 10.1016/j.eplepsyres.2005.03.008 contributor: fullname: Dahlin – volume: 65 start-page: 1810 year: 2005 ident: 10.1016/j.neuron.2012.03.032_bib48 article-title: Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy publication-title: Neurology doi: 10.1212/01.wnl.0000187071.24292.9e contributor: fullname: Pfeifer – volume: 36 start-page: 281 year: 2007 ident: 10.1016/j.neuron.2012.03.032_bib24 article-title: The neuropharmacology of the ketogenic diet publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2007.02.008 contributor: fullname: Hartman – year: 1998 ident: 10.1016/j.neuron.2012.03.032_bib1 contributor: fullname: Banker – volume: 44 start-page: 26 issue: Suppl 7 year: 2003 ident: 10.1016/j.neuron.2012.03.032_bib56 article-title: Assessing the efficacy of antiepileptic treatments: the ketogenic diet publication-title: Epilepsia doi: 10.1046/j.1528-1157.44.s7.4.x contributor: fullname: Thiele – volume: 27 start-page: S53 issue: Suppl 1 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib11 article-title: BAD: undertaker by night, candyman by day publication-title: Oncogene doi: 10.1038/onc.2009.44 contributor: fullname: Danial – volume: 6 start-page: 41 year: 2000 ident: 10.1016/j.neuron.2012.03.032_bib15 article-title: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation publication-title: Mol. Cell doi: 10.1016/S1097-2765(05)00012-2 contributor: fullname: Datta – volume: 401 start-page: 59 year: 1997 ident: 10.1016/j.neuron.2012.03.032_bib35 article-title: Overlapping distribution of KATP channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain publication-title: FEBS Lett. doi: 10.1016/S0014-5793(96)01438-X contributor: fullname: Karschin – volume: 71 start-page: 759 year: 2003 ident: 10.1016/j.neuron.2012.03.032_bib20 article-title: Variations in spare electron transport chain capacity: The answer to an old riddle? publication-title: J. Neurosci. Res. doi: 10.1002/jnr.10553 contributor: fullname: Fern – volume: 99 start-page: 7 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib50 article-title: Modeling KATP channel gating and its regulation publication-title: Prog. Biophys. Mol. Biol. doi: 10.1016/j.pbiomolbio.2008.10.002 contributor: fullname: Proks – volume: 116 start-page: 205 year: 2004 ident: 10.1016/j.neuron.2012.03.032_bib12 article-title: Cell death: critical control points publication-title: Cell doi: 10.1016/S0092-8674(04)00046-7 contributor: fullname: Danial – volume: 109 start-page: 24 issue: Suppl 1 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib65 article-title: Direct measurement of oxidative metabolism in the living brain by microdialysis: a review publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2009.05941.x contributor: fullname: Zielke – volume: 49 start-page: 80 issue: Suppl 8 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib60 article-title: Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet publication-title: Epilepsia doi: 10.1111/j.1528-1167.2008.01843.x contributor: fullname: Yellen – volume: 292 start-page: C125 year: 2007 ident: 10.1016/j.neuron.2012.03.032_bib59 article-title: Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00247.2006 contributor: fullname: Wu – volume: 232 start-page: 195 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib32 article-title: Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2011.09.001 contributor: fullname: Jeong – volume: 70 start-page: 758 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib33 article-title: Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission publication-title: Neuron doi: 10.1016/j.neuron.2011.04.004 contributor: fullname: Jiao – volume: 53 start-page: 119 year: 2003 ident: 10.1016/j.neuron.2012.03.032_bib46 article-title: The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice publication-title: Epilepsy Res. doi: 10.1016/S0920-1211(02)00262-0 contributor: fullname: Noh – volume: 6 start-page: 1 year: 1990 ident: 10.1016/j.neuron.2012.03.032_bib7 article-title: Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern publication-title: Epilepsy Res. doi: 10.1016/0920-1211(90)90002-D contributor: fullname: Browning – volume: 68 start-page: 99 year: 2010 ident: 10.1016/j.neuron.2012.03.032_bib34 article-title: Metabolic control of vesicular glutamate transport and release publication-title: Neuron doi: 10.1016/j.neuron.2010.09.002 contributor: fullname: Juge – volume: 1787 start-page: 1416 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib45 article-title: Mitochondrial calcium function and dysfunction in the central nervous system publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbabio.2009.03.010 contributor: fullname: Nicholls – year: 2004 ident: 10.1016/j.neuron.2012.03.032_bib52 contributor: fullname: Stafstrom – volume: 168 start-page: 443 year: 2010 ident: 10.1016/j.neuron.2012.03.032_bib18 article-title: Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.03.057 contributor: fullname: Engel – volume: 8 start-page: 1752 year: 2005 ident: 10.1016/j.neuron.2012.03.032_bib5 article-title: BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures publication-title: Nat. Neurosci. doi: 10.1038/nn1573 contributor: fullname: Brenner – volume: 49 start-page: 42 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib49 article-title: Low glycemic index treatment: implementation and new insights into efficacy publication-title: Epilepsia doi: 10.1111/j.1528-1167.2008.01832.x contributor: fullname: Pfeifer – volume: 31 start-page: 1196 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib19 article-title: In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2011.26 contributor: fullname: Engel – volume: 50 start-page: 1109 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib43 article-title: A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy publication-title: Epilepsia doi: 10.1111/j.1528-1167.2008.01870.x contributor: fullname: Neal – volume: 424 start-page: 952 year: 2003 ident: 10.1016/j.neuron.2012.03.032_bib13 article-title: BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis publication-title: Nature doi: 10.1038/nature01825 contributor: fullname: Danial – volume: 297 start-page: E578 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib29 article-title: The Randle cycle revisited: a new head for an old hat publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00093.2009 contributor: fullname: Hue – volume: 11 start-page: 816 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib66 article-title: Seizure termination by acidosis depends on ASIC1a publication-title: Nat. Neurosci. doi: 10.1038/nn.2132 contributor: fullname: Ziemann – volume: 814 start-page: 41 year: 1998 ident: 10.1016/j.neuron.2012.03.032_bib17 article-title: Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain publication-title: Brain Res. doi: 10.1016/S0006-8993(98)00956-1 contributor: fullname: Dunn-Meynell – volume: 514 start-page: 327 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib64 article-title: Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus publication-title: J. Physiol. contributor: fullname: Zawar – volume: 7 start-page: 273 year: 1992 ident: 10.1016/j.neuron.2012.03.032_bib26 article-title: The dentate gyrus as a regulated gate for the propagation of epileptiform activity publication-title: Epilepsy Res. Suppl. contributor: fullname: Heinemann – volume: 191 start-page: 79 year: 1980 ident: 10.1016/j.neuron.2012.03.032_bib2 article-title: The role of epileptic activity in hippocampal and “remote” cerebral lesions induced by kainic acid publication-title: Brain Res. doi: 10.1016/0006-8993(80)90316-9 contributor: fullname: Ben-Ari – volume: 121 start-page: 2679 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib40 article-title: A ketogenic diet suppresses seizures in mice through adenosine A1 receptors publication-title: J. Clin. Invest. doi: 10.1172/JCI57813 contributor: fullname: Masino – volume: 102 start-page: 11272 year: 2005 ident: 10.1016/j.neuron.2012.03.032_bib54 article-title: Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0504783102 contributor: fullname: Takeuchi – volume: 17 start-page: 459 year: 2010 ident: 10.1016/j.neuron.2012.03.032_bib42 article-title: Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus publication-title: Cell Death Differ. doi: 10.1038/cdd.2009.134 contributor: fullname: Murphy – volume: 9 start-page: 47 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib62 article-title: The BCL-2 protein family: opposing activities that mediate cell death publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2308 contributor: fullname: Youle – volume: 163 start-page: 601 year: 2007 ident: 10.1016/j.neuron.2012.03.032_bib28 article-title: The dentate gyrus as a filter or gate: a look back and a look ahead publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(07)63032-5 contributor: fullname: Hsu – volume: 31 start-page: 8689 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib55 article-title: Single KATP channel opening in response to action potential firing in mouse dentate granule neurons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5951-10.2011 contributor: fullname: Tanner – volume: 14 start-page: 144 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib14 article-title: Dual role of proapoptotic BAD in insulin secretion and beta cell survival publication-title: Nat. Med. doi: 10.1038/nm1717 contributor: fullname: Danial – volume: 41 start-page: 1235 year: 2000 ident: 10.1016/j.neuron.2012.03.032_bib25 article-title: Anticonvulsant action of topiramate against motor seizures in developing rats publication-title: Epilepsia doi: 10.1111/j.1528-1157.2000.tb04600.x contributor: fullname: Haugvicová – volume: 440 start-page: 470 year: 2006 ident: 10.1016/j.neuron.2012.03.032_bib44 article-title: KATP channels as molecular sensors of cellular metabolism publication-title: Nature doi: 10.1038/nature04711 contributor: fullname: Nichols – volume: 8 start-page: 200 year: 1997 ident: 10.1016/j.neuron.2012.03.032_bib21 article-title: Mapping murine loci for seizure response to kainic acid publication-title: Mamm. Genome doi: 10.1007/s003359900389 contributor: fullname: Ferraro – volume: 46 start-page: 1589 year: 1967 ident: 10.1016/j.neuron.2012.03.032_bib47 article-title: Brain metabolism during fasting publication-title: J. Clin. Invest. doi: 10.1172/JCI105650 contributor: fullname: Owen – volume: 66 start-page: 931 year: 2001 ident: 10.1016/j.neuron.2012.03.032_bib63 article-title: Ketogenic diet, amino acid metabolism, and seizure control publication-title: J. Neurosci. Res. doi: 10.1002/jnr.10083 contributor: fullname: Yudkoff – volume: 3 start-page: 331 year: 1978 ident: 10.1016/j.neuron.2012.03.032_bib16 article-title: Chronic ketosis and cerebral metabolism publication-title: Ann. Neurol. doi: 10.1002/ana.410030410 contributor: fullname: DeVivo – volume: 32 start-page: 231 year: 2010 ident: 10.1016/j.neuron.2012.03.032_bib39 article-title: Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2010.07345.x contributor: fullname: MacAskill – start-page: 601 year: 2005 ident: 10.1016/j.neuron.2012.03.032_bib57 article-title: Behavioral Characterization of Seizures in Rats contributor: fullname: Velíšková – volume: 37 start-page: 171 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib51 article-title: Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet publication-title: Epilepsy Res. doi: 10.1016/S0920-1211(99)00069-8 contributor: fullname: Schwartzkroin – volume: 95 start-page: 10402 year: 1998 ident: 10.1016/j.neuron.2012.03.032_bib41 article-title: Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.18.10402 contributor: fullname: Miki – volume: 400 start-page: 886 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib61 article-title: Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis publication-title: Nature doi: 10.1038/23730 contributor: fullname: Yin – volume: 49 start-page: 615 year: 2003 ident: 10.1016/j.neuron.2012.03.032_bib58 article-title: In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy—exploration of GABA levels in a ketogenic diet publication-title: Magn. Reson. Med. doi: 10.1002/mrm.10429 contributor: fullname: Wang – volume: 9 start-page: 1382 year: 2006 ident: 10.1016/j.neuron.2012.03.032_bib23 article-title: 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure publication-title: Nat. Neurosci. doi: 10.1038/nn1791 contributor: fullname: Garriga-Canut – volume: 40 start-page: S23 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib8 article-title: Chronic epileptogenic cellular alterations in the limbic system after status epilepticus publication-title: Epilepsia doi: 10.1111/j.1528-1157.1999.tb00875.x contributor: fullname: Coulter – volume: 37 start-page: 299 year: 2010 ident: 10.1016/j.neuron.2012.03.032_bib9 article-title: The BCL-2 family reunion publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.01.025 contributor: fullname: Chipuk – volume: 435 start-page: 297 year: 2011 ident: 10.1016/j.neuron.2012.03.032_bib4 article-title: Assessing mitochondrial dysfunction in cells publication-title: Biochem. J. doi: 10.1042/BJ20110162 contributor: fullname: Brand – volume: 19 start-page: 6733 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib22 article-title: Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.19-16-06733.1999 contributor: fullname: Ferraro – start-page: 399 year: 1994 ident: 10.1016/j.neuron.2012.03.032_bib6 article-title: Anatomy of Generalized Convulsive Seizures contributor: fullname: Browning – volume: 99 start-page: 1515 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib27 article-title: Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission publication-title: J. Neurophysiol. doi: 10.1152/jn.00598.2007 contributor: fullname: Hickman – volume: 353 start-page: 191 year: 1998 ident: 10.1016/j.neuron.2012.03.032_bib36 article-title: Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(98)00410-5 contributor: fullname: Klitgaard – volume: 27 start-page: 3618 year: 2007 ident: 10.1016/j.neuron.2012.03.032_bib38 article-title: Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0132-07.2007 contributor: fullname: Ma – volume: 40 start-page: 138 year: 1999 ident: 10.1016/j.neuron.2012.03.032_bib3 article-title: A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat publication-title: Epilepsia doi: 10.1111/j.1528-1157.1999.tb02066.x contributor: fullname: Bough – volume: 65 start-page: 435 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib53 article-title: Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models publication-title: Ann. Neurol. doi: 10.1002/ana.21603 contributor: fullname: Stafstrom – volume: 101 start-page: 1660 year: 2009 ident: 10.1016/j.neuron.2012.03.032_bib37 article-title: A simple quantitative method for analyzing electrographic status epilepticus in rats publication-title: J. Neurophysiol. doi: 10.1152/jn.91062.2008 contributor: fullname: Lehmkuhle – volume: 106 start-page: 1044 year: 2008 ident: 10.1016/j.neuron.2012.03.032_bib31 article-title: The ketogenic diet increases mitochondrial glutathione levels publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2008.05460.x contributor: fullname: Jarrett |
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