Sphingosine-1-Phosphate: Boon and Bane for the Brain
Sphingosine-1-phosphate (S1P), an evolutionary conserved bioactive lipid, is essential for brain development, but might also exert detrimental effects in terminally differentiated post-mitotic neurons. Its concentration in the brain is tightly regulated by specific kinases and phosphatases, and main...
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| Published in | Cellular physiology and biochemistry Vol. 34; no. 1; pp. 148 - 157 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Basel, Switzerland
Cell Physiol Biochem Press GmbH & Co KG
2014
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| Abstract | Sphingosine-1-phosphate (S1P), an evolutionary conserved bioactive lipid, is essential for brain development, but might also exert detrimental effects in terminally differentiated post-mitotic neurons. Its concentration in the brain is tightly regulated by specific kinases and phosphatases, and mainly by the S1P degrading enzyme, S1P-lyase (S1PL). The role of S1P in neurons was initially studied in primary cultures by using structural analogues. During the last 3 years generation of a S1PL deficient mouse model substantially promoted our knowledge on the functional role of S1P metabolism in the brain, and its potential relation to neurodegenerative diseases. However, our understanding of the molecular mechanisms that underlie the physiological and pathophysiological actions of S1P in neurons remains rather scarce. |
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| AbstractList | Sphingosine-1-phosphate (S1P), an evolutionary conserved bioactive lipid, is essential for brain development, but might also exert detrimental effects in terminally differentiated post-mitotic neurons. Its concentration in the brain is tightly regulated by specific kinases and phosphatases, and mainly by the S1P degrading enzyme, S1P-lyase (S1PL). The role of S1P in neurons was initially studied in primary cultures by using structural analogues. During the last 3 years generation of a S1PL deficient mouse model substantially promoted our knowledge on the functional role of S1P metabolism in the brain, and its potential relation to neurodegenerative diseases. However, our understanding of the molecular mechanisms that underlie the physiological and pathophysiological actions of S1P in neurons remains rather scarce. |
| Author | Walter, Jochen Hagen-Euteneuer, Nadine van Echten-Deckert, Gerhild Karaca, Ilker |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24977488$$D View this record in MEDLINE/PubMed |
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| Keywords | Amyloid beta FTY720 (fingolimod) Alzheimer’s disease Neurodegeneration Sphingosine-1-phosphate Tau S1P-lyase cis-4-methylsphingosine |
| Language | English |
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| References | Asle-Rousta M, Kolahdooz Z, Oryan S, Ahmadiani A, Dargahi L: FTY720 (fingolimod) attenuates beta-amyloid peptide (abeta42)-induced impairment of spatial learning and memory in rats. J Mol Neurosci 2013;50:524-532.2343593810.1007/s12031-013-9979-6 Katsel P, Li C, Haroutunian V: Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: A shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? Neurochem Res 2007;32:845-856.1734240710.1007/s11064-007-9297-x Tanzi RE: The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2012;2: pii: a006296.2302812610.1101/cshperspect.a006296 Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S: Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996;381:800-803.865728510.1038/381800a0 Bär T, Kratzer B, Wild R, Sandhoff K, Schmidt RR: Synthesis of methyl-branched sphingosines. Liebigs Ann Chem 1993:419-426.10.1002/jlac.199319930168 Bagdanoff JT, Donoviel MS, Nouraldeen A, Tarver J, Fu Q, Carlsen M, Jessop TC, Zhang H, Hazelwood J, Nguyen H, Baugh SD, Gardyan M, Terranova KM, Barbosa J, Yan J, Bednarz M, Layek S, Courtney LF, Taylor J, Digeorge-Foushee AM, Gopinathan S, Bruce D, Smith T, Moran L, O'Neill E, Kramer J, Lai Z, Kimball SD, Liu Q, Sun W, Yu S, Swaffield J, Wilson A, Main A, Carson KG, Oravecz T, Augeri DJ: Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders. J Med Chem 2009;52:3941-3953.1948953810.1021/jm900278w van Echten-Deckert G, Zschoche A, Bar T, Schmidt RR, Raths A, Heinemann T, Sandhoff K: Cis-4-methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J Biol Chem 1997;272:15825-15833.918848010.1074/jbc.272.25.15825 Haass C, Kaether C, Thinakaran G, Sisodia S: Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2012;2:a006270.2255349310.1101/cshperspect.a006270 Meyer zu Heringdorf D, Liliom K, Schaefer M, Danneberg K, Jaggar JH, Tigyi G, Jakobs KH: Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett 2003;554:443-449.1462310910.1016/S0014-5793(03)01219-5 Natzker S, Heinemann T, Figueroa-Perez S, Schnieders B, Schmidt RR, Sandhoff K, van Echten-Deckert G: Cis-4-methylsphingosine phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK mitogen-activated protein kinases. Biol Chem 2002;383:1885-1894.1255372510.1515/BC.2002.212 Maceyka M, Payne SG, Milstien S, Spiegel S: Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 2002;1585:193-201.1253155410.1016/S1388-1981(02)00341-4 van Echten-Deckert G, Herget T: Sphingolipid metabolism in neural cells. Biochim Biophys Acta 2006;1758:1978-1994.1684343210.1016/j.bbamem.2006.06.009 Hagen N, Van Veldhoven PP, Proia RL, Park H, Merrill AH Jr, van Echten-Deckert G: Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons. J Biol Chem 2009;284:11346-11353.1925169110.1074/jbc.M807336200 Ceccom J, Loukh N, Lauwers-Cances V, Touriol C, Nicaise Y, Gentil C, Uro-Coste E, Pitson S, Maurage CA, Duyckaerts C, Cuvillier O, Delisle MB: Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease. Acta Neuropathol Commun 2014;2:12.2446811310.1186/2051-5960-2-12 Kajimoto T, Okada T, Yu H, Goparaju SK, Jahangeer S, Nakamura S: Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Mol Cell Biol 2007;27:3429-3440.1732503910.1128/MCB.01465-06 Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000;403:98-103.1063876110.1038/47513 Hagen N, Hans M, Hartmann D, Swandulla D, van Echten-Deckert G: Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ 2011;18:1356-1365.2133107910.1038/cdd.2011.7 Spiegel S, Milstien S: Sphingosine-1-phosphate: Signaling inside and out. FEBS Lett 2000;476:55-57.1087825010.1016/S0014-5793(00)01670-7 Selkoe D, Mandelkow E, Holtzman D: Deciphering Alzheimer disease. Cold Spring Harb Perspect Med 2012;2:a011460.2231572310.1101/cshperspect.a011460 Naetzker S, Hagen N, Echten-Deckert G: Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. Genes Cells 2006;11:269-279.1648331510.1111/j.1365-2443.2006.00933.x Lee MS, Tsai LH: Cdk5: One of the links between senile plaques and neurofibrillary tangles? J Alzheimers Dis 2003;5:127-137.12719630 Simons K, Gerl MJ: Revitalizing membrane rafts: New tools and insights. Nat Rev Mol Cell Biol 2010;11:688-699.2086187910.1038/nrm2977 Lane RM, Farlow MR: Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. J Lipid Res 2005;46:949-968.1571658610.1194/jlr.M400486-JLR200 Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S: Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 1998;273:23722-23728.972697910.1074/jbc.273.37.23722 Ghosh TK, Bian J, Gill DL: Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 1994;269:22628-22635.8077214 Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH: Conversion of p35 to p25 deregulates CDK5 activity and promotes neurodegeneration. Nature 1999;402:615-622.1060446710.1038/45159 Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL: Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000;106:951-961.1103285510.1172/JCI10905 Hannun YA, Obeid LM: The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind. J Biol Chem 2002;277:25847-25850.1201110310.1074/jbc.R200008200 Hung WC, Chuang LY: Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product. Biochem Biophys Res Commun 1996;229:11-15.895407610.1006/bbrc.1996.1750 Harada J, Foley M, Moskowitz MA, Waeber C: Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. J Neurochem 2004;88:1026-1039.1475682510.1046/j.1471-4159.2003.02219.x Walter J, van Echten-Deckert G: Cross-talk of membrane lipids and Alzheimer-related proteins. Mol Neurodegener 2013;8:34.2414820510.1186/1750-1326-8-34 Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD: Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res 2012;53:1920-1931.2278100110.1194/jlr.M028084 van Echten-Deckert G, Walter J: Sphingolipids: Critical players in Alzheimer's disease. Prog Lipid Res 2012;51:378-393.2283578410.1016/j.plipres.2012.07.001 Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Gräler MH, van Echten-Deckert G, Walter J: Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. J Biol Chem 2014;289:16761-16772.2480818010.1074/jbc.M113.535500 De Strooper B, Vassar R, Golde T: The secretases: Enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 2010;6:99-107.2013999910.1038/nrneurol.2009.218 Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H: Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med 2004;10:712-718.1519508610.1038/nm1060 Moore AN, Kampfl AW, Zhao X, Hayes RL, Dash PK: Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience 1999;94:405-415.1057920410.1016/S0306-4522(99)00288-2 Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL: Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005;25:11113-11121.1631453110.1128/MCB.25.24.11113-11121.2005 Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH, Kolesnick RN, Tilly JL: Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med 2000;6:1109-1114.1101714110.1038/80442 Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009;325:1254-1257.1972965610.1126/science.1176709 Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, Hajdu R, Rosenbach M, Keohane CA, Mandala S, Spiegel S, Proia RL: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 2004;279:52487-52492.1545920110.1074/jbc.M406512200 Huang Y, Tanimukai H, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX: Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. Eur J Neurosci 2004;20:3489-3497.1561018110.1111/j.1460-9568.2004.03852.x Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 2000;275:19513-19520.1075141410.1074/jbc.M002759200 St George-Hyslop PH, Petit A: Molecular biology and genetics of Alzheimer's disease. C R Biol 2005;328:119-130.1577099810.1016/j.crvi.2004.10.013 Don AS, Martinez-Lamenca C, Webb WR, Proia RL, Roberts E, Rosen H: Es |
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| Title | Sphingosine-1-Phosphate: Boon and Bane for the Brain |
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