A Novel MRI Tracer-Based Method for Measuring Water Diffusion in the Extracellular Space of the Rat Brain (December2013)

• Published in: IEEE journal of biomedical and health informatics Vol. 18; no. 3; pp. 978 - 983
• Main Authors: Han, Hongbin, Shi, Chunyan, Fu, Yu, Zuo, Long, Lee, Kejia, He, Qingyuan, Han, Haojun
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.05.2014; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Animals; Biomedical measurement; Brain; Brain - cytology; Brain - metabolism; Brain Chemistry; Brain interstitial fluid; Diffusion; Educational institutions; Extracellular; Extracellular Fluid - chemistry; Extracellular Fluid - metabolism; extracellular space (ECS); Gadolinium DTPA - chemistry; Gadolinium DTPA - pharmacokinetics; gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA); Imaging, Three-Dimensional - methods; Magnetic resonance imaging; magnetic resonance imaging (MRI); Magnetic Resonance Imaging - methods; Male; NMR; Nuclear magnetic resonance; Probes; Rats; Rats, Sprague-Dawley; Rodents; Time measurement; Water - chemistry; Water - metabolism; water diffusion

We proposed a novel MRI tracer-based method for the determination of water diffusion in the brain extracellular space (ECS). The measuring system was validated in 32 Sprague Dawley rats. The rats were randomly divided into four groups with different injection sites: 1) caudate nucleus (Cn.); 2) thal...