PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold
We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds ( 8a, 8b, and 15a) were shown exhibit inhibitory ac...
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Published in | Bioorganic & medicinal chemistry Vol. 18; no. 8; pp. 2719 - 2724 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
15.04.2008
Elsevier |
Subjects | |
Online Access | Get full text |
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