The Crystal Structure of Human Cyclin B

• Published in: Cell cycle (Georgetown, Tex.) Vol. 6; no. 11; pp. 1342 - 1349
• Main Authors: Petri, Edward T., Errico, Alessia, Escobedo, Lourdes, Hunt, Tim, Basavappa, Ravi
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.06.2007
• Subjects: Amino Acid Sequence; Animals; Binding; Biology; Bioscience; Calcium; Cancer; CDC2 Protein Kinase - metabolism; Cell; Consensus Sequence; Crystallization; Crystallography, X-Ray; Cycle; Cyclin A - chemistry; Cyclin B - antagonists & inhibitors; Cyclin B - chemistry; Cyclin B - genetics; Cyclin B - isolation & purification; Cyclin B - physiology; Cyclin B1; Cyclin E - chemistry; Cyclin-Dependent Kinases - metabolism; Escherichia coli; Female; Histones - metabolism; Humans; Landes; Models, Molecular; Molecular Sequence Data; Oocytes - enzymology; Organogenesis; Phosphorylation; Protein Conformation; Protein Kinases - analysis; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - isolation & purification; Sequence Alignment; Sequence Homology, Amino Acid; Solubility; Structure-Activity Relationship; Xenopus laevis

Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate spe...