Saliva and Plasma Neutralizing Activity Induced by the Administration of a Third bnt162b2 Vaccine Dose

• Published in: International journal of molecular sciences Vol. 23; no. 22; p. 14341
• Main Authors: Garziano, Micaela, Utyro, Olga, Strizzi, Sergio, Vanetti, Claudia, Saulle, Irma, Conforti, Chiara, Cicilano, Federica, Ardizzone, Francesco, Cappelletti, Gioia, Clerici, Mario, Limanaqi, Fiona, Biasin, Mara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.11.2022; MDPI
• Subjects: Antigens; BNT162 Vaccine; Coronaviruses; COVID-19 - prevention & control; COVID-19 vaccines; Disease transmission; Humans; Infections; Plasma; Saliva; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Vaccines; Viral infections; saliva; SARS-CoV-2; neutralizing activity; vaccine; variants; booster dose

The BNT162b2 vaccine induces neutralizing activity (NA) in serum, but no data are available on whether a third-dose activates specific-immunity within the oral mucosa, representing the primary route of viral-entry. To carefully address this issue, we investigated if such immunity is boosted by SARS-...