Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes

• Published in: The Journal of cell biology Vol. 220; no. 9; p. 1
• Main Authors: Lancaster, Charlene E, Fountain, Aaron, Dayam, Roaya M, Somerville, Elliott, Sheth, Javal, Jacobelli, Vanessa, Somerville, Alex, Terebiznik, Mauricio R, Botelho, Roberto J
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.09.2021
• Subjects: Actin; Actin Cytoskeleton - metabolism; Actin Cytoskeleton - microbiology; Actin Cytoskeleton - ultrastructure; Actins - genetics; Actins - metabolism; Animals; Biodegradation; Clathrin; Clathrin - genetics; Clathrin - metabolism; Degradation; Escherichia coli - chemistry; Exocytosis; Fragmentation; Gene Expression; Genes, Reporter; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Immunology; Lysosomes; Lysosomes - metabolism; Lysosomes - microbiology; Lysosomes - ultrastructure; Macrophages; Membrane Fusion; Membranes; Mice; Microtubules - metabolism; Microtubules - microbiology; Microtubules - ultrastructure; Organelles; Phagocytes; Phagocytosis; Phagocytosis - physiology; Phagolysosomes; Phagosomes; Phagosomes - metabolism; Phagosomes - microbiology; Phagosomes - ultrastructure; Proteolysis; RAW 264.7 Cells; Trafficking

Phagocytes engulf unwanted particles into phagosomes that then fuse with lysosomes to degrade the enclosed particles. Ultimately, phagosomes must be recycled to help recover membrane resources that were consumed during phagocytosis and phagosome maturation, a process referred to as "phagosome r...